KOR Activators
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trimebutine maleate | 34140-59-5 | sc-204928 sc-204928A | 100 mg 5 g | $39.00 $80.00 | 6 | |
Trimebutine maleate exhibits unique interactions with kappa-opioid receptors (KOR), influencing signaling pathways that modulate pain perception and gastrointestinal motility. Its molecular structure allows for selective binding, leading to distinct allosteric effects that alter receptor conformation. The compound's amphiphilic characteristics enhance its ability to traverse biological membranes, impacting its distribution and interaction kinetics within cellular environments. This behavior underscores its role in modulating receptor activity. | ||||||
Matrine | 519-02-8 | sc-205741 sc-205741A | 100 mg 500 mg | $242.00 $544.00 | ||
Matrine demonstrates intriguing interactions with kappa-opioid receptors (KOR), characterized by its ability to stabilize receptor conformations through specific hydrogen bonding and hydrophobic interactions. This compound's unique stereochemistry facilitates selective receptor engagement, influencing downstream signaling cascades. Additionally, Matrine's lipophilic nature enhances its permeability across lipid membranes, affecting its bioavailability and interaction dynamics within cellular systems, thereby modulating receptor functionality. | ||||||
(+)-U-50488 hydrochloride | 67198-17-8 | sc-203712 sc-203712A | 10 mg 50 mg | $155.00 $645.00 | ||
(+)-U-50488 hydrochloride exhibits a distinctive affinity for kappa-opioid receptors (KOR), engaging in nuanced molecular interactions that promote receptor activation. Its unique stereochemical configuration allows for precise binding, influencing receptor dynamics and subsequent intracellular signaling pathways. The compound's solubility characteristics enhance its interaction with lipid bilayers, facilitating effective membrane penetration and modulating receptor activity through altered conformational states. | ||||||
ICI-204,448 hydrochloride | 121264-04-8 | sc-203082 sc-203082A | 5 mg 25 mg | $300.00 $700.00 | ||
ICI-204,448 hydrochloride is characterized by its selective binding to kappa-opioid receptors (KOR), showcasing a unique interaction profile that stabilizes specific receptor conformations. This compound's structural features enable it to engage in distinct hydrogen bonding and hydrophobic interactions, influencing receptor activation kinetics. Its physicochemical properties, including enhanced solubility, allow for efficient distribution within biological membranes, potentially affecting downstream signaling cascades. | ||||||
(±)-U-50488 hydrochloride | 67197-96-0 | sc-203713 | 1 mg | $99.00 | ||
(±)-U-50488 hydrochloride exhibits a remarkable affinity for kappa-opioid receptors (KOR), facilitating unique allosteric modulation that alters receptor dynamics. Its molecular architecture promotes specific electrostatic interactions, enhancing binding efficacy and selectivity. The compound's ability to traverse lipid bilayers is attributed to its optimized hydrophobic characteristics, which may influence receptor desensitization and internalization pathways, ultimately impacting cellular signaling networks. | ||||||
(−)-U-50488 hydrochloride | 67198-19-0 | sc-203714 sc-203714A | 5 mg 25 mg | $140.00 $500.00 | ||
(-)-U-50488 hydrochloride is characterized by its selective engagement with kappa-opioid receptors (KOR), where it induces conformational changes that modulate receptor activity. The compound's stereochemistry plays a crucial role in its binding affinity, allowing for distinct interactions with receptor sites. Its solubility profile suggests favorable interactions with biological membranes, potentially influencing downstream signaling cascades and receptor trafficking mechanisms. | ||||||
Trimebutine base | 39133-31-8 | sc-204927 sc-204927A | 25 g 50 g | $91.00 $400.00 | ||
Trimebutine base exhibits a unique affinity for kappa-opioid receptors (KOR), facilitating specific ligand-receptor interactions that alter receptor conformation. Its structural features enable it to stabilize receptor states, influencing downstream signaling pathways. The compound's hydrophilic and lipophilic balance enhances its ability to traverse cellular membranes, potentially affecting receptor localization and interaction dynamics within various cellular environments. | ||||||
U-54494A hydrochloride | 112465-94-8 | sc-200479 sc-200479A | 10 mg 50 mg | $135.00 $595.00 | ||
U-54494A hydrochloride demonstrates a distinctive binding profile at kappa-opioid receptors (KOR), characterized by its ability to induce conformational changes that modulate receptor activity. The compound's unique steric and electronic properties facilitate selective interactions with receptor sites, influencing the kinetics of ligand binding and dissociation. Its solubility characteristics may also impact its distribution in biological systems, affecting receptor engagement and signaling cascades. | ||||||
ICI-199,441 hydrochloride | 115199-84-3 | sc-203081 sc-203081A sc-203081B | 1 mg 5 mg 25 mg | $30.00 $145.00 $400.00 | 1 | |
ICI-199,441 hydrochloride exhibits a remarkable affinity for kappa-opioid receptors (KOR), showcasing a unique mechanism of action through allosteric modulation. Its structural conformation allows for specific interactions with receptor domains, enhancing or inhibiting downstream signaling pathways. The compound's dynamic binding kinetics contribute to its distinct pharmacological profile, while its physicochemical properties influence its interaction with lipid membranes, potentially affecting cellular uptake and receptor localization. | ||||||
GR 89696 fumarate | 126766-32-3 | sc-203982 sc-203982A | 10 mg 50 mg | $184.00 $759.00 | ||
GR 89696 fumarate is characterized by its selective binding to kappa-opioid receptors (KOR), where it engages in unique ligand-receptor interactions that stabilize specific conformational states. This compound demonstrates a nuanced modulation of receptor activity, influencing G-protein coupling and downstream signaling cascades. Its solubility and stability in various environments enhance its potential for diverse interactions, impacting its overall bioavailability and receptor affinity. | ||||||