KMO Inhibitors
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ro 61-8048 | 199666-03-0 | sc-204240 sc-204240A | 10 mg 50 mg | $166.00 $515.00 | 1 | |
Ro 61-8048 acts as a potent inhibitor of kynurenine monooxygenase (KMO), exhibiting a unique binding mechanism that disrupts the enzyme's catalytic cycle. Its structural features allow for specific interactions with the enzyme's active site, promoting conformational changes that hinder substrate access. The compound's reaction kinetics reveal a rapid association phase, followed by a slower dissociation, indicating a strong affinity. Additionally, its lipophilicity enhances membrane permeability, influencing its bioavailability in various environments. | ||||||
(±)-3-(3-Nitrobenzoyl)alanine hydrochloride | sc-220850 | 5 mg | $300.00 | |||
(±)-3-(3-Nitrobenzoyl)alanine hydrochloride serves as a selective inhibitor of kynurenine monooxygenase (KMO), characterized by its ability to form stable interactions with the enzyme's active site. The presence of the nitro group enhances electron-withdrawing properties, facilitating unique hydrogen bonding and π-π stacking interactions. This compound exhibits distinct reaction kinetics, with a notable preference for specific conformational states of KMO, ultimately modulating its enzymatic activity. Its solubility profile suggests favorable interactions in polar environments, impacting its distribution and reactivity. | ||||||
Bismuth(III) subsalicylate | 14882-18-9 | sc-227416 | 100 g | $30.00 | ||
Non-specific KMO interaction, alters enzyme conformation. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Competitively inhibits KMO by occupying the active site. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
Inhibits KMO by binding to the ATP-binding site. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates KMO activity through indirect multi-target effects. | ||||||
Phenethyl-hydrazine | 51-71-8 | sc-331686 | 500 mg | $396.00 | ||
Non-selective monoamine oxidase inhibitor that also inhibits KMO. | ||||||