Klp3 Inhibitors
Chemical inhibitors of Klp3 disrupt its function in cell division by targeting various proteins involved in mitotic spindle formation and chromosome alignment. Monastrol, a specific inhibitor of the motor protein Eg5, directly impedes the formation of the mitotic spindle, a structure critical for chromosome segregation to which Klp3 contributes. S-Trityl-L-cysteine operates similarly by selectively inhibiting Eg5, leading to mitotic arrest due to an incomplete spindle apparatus. Ispinesib and Filanesib, both targeting the kinesin spindle protein (KSP), disrupt the microtubule dynamics essential for spindle assembly, thereby indirectly restricting Klp3's activity. Dimethylenastron further compounds this effect by binding to Eg5 and altering microtubule function, which is necessary for Klp3's role in cell division.
Additionally, HR22C16 and GSK923295 inhibit CENP-E, a protein crucial for chromosome alignment during mitosis. The inhibition of CENP-E by these chemicals leads to the destabilization of microtubule architecture, thereby limiting Klp3's ability to facilitate correct chromosome segregation. Paprotrain, which selectively inhibits kinesin MKLP-2, disrupts cytokinesis, a process that is also influenced by Klp3. This results in a failure of cell division, which indirectly affects Klp3's functionality. Chemicals like ON 01910.Na and Reversine target multiple kinases that regulate the spindle assembly checkpoint and mitotic spindle formation, respectively. By altering the function of these kinases, these inhibitors cause a ripple effect that disrupts the normal operation of the spindle apparatus, consequently inhibiting Klp3. ZM447439's inhibition of Aurora kinases A and B affects chromosomal alignment and segregation, further implicating the indirect inhibition of Klp3 due to its reliance on these processes for its function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a cell-permeable small molecule inhibitor known to specifically target kinesin-5 (Eg5), a motor protein related to Klp3's function in mitotic spindle formation. By inhibiting Eg5 and thereby disrupting spindle polymer dynamics, Monastrol can indirectly lead to the inhibition of Klp3 activity, as Klp3 function is closely related to spindle assembly and maintenance. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a selective inhibitor of the mitotic kinesin Eg5 which is essential for spindle formation, similar to Klp3's role. By blocking Eg5 function, this chemical induces mitotic arrest, which would prevent the normal functioning of Klp3 due to the disruption of the mitotic spindle structure it operates within. | ||||||
Ispinesib | 336113-53-2 | sc-364747 | 10 mg | $505.00 | ||
Ispinesib selectively targets kinesin spindle protein (KSP), another kinesin motor protein involved in spindle dynamics. The inhibition of KSP results in the disruption of microtubule dynamics, which indirectly inhibits Klp3 activity due to the interdependency of their functions in cell division. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
Dimethylenastron is a potent inhibitor of kinesin Eg5. Its binding to Eg5 disrupts microtubule dynamics, which is essential for Klp3's role in the mitotic spindle. As a result, by inhibiting Eg5, it indirectly impedes Klp3's function in cell division. | ||||||
AZ 3146 | 1124329-14-1 | sc-361114 sc-361114A | 10 mg 50 mg | $218.00 $905.00 | 7 | |
AZ3146 is a Mps1 kinase inhibitor that disrupts the spindle assembly checkpoint, which is crucial for correct mitotic progression, a process in which Klp3 is involved. By inhibiting this checkpoint, AZ3146 indirectly inhibits Klp3 by preventing the accurate segregation of chromosomes, a process Klp3 is associated with. | ||||||
GSK 923295 | 1088965-37-0 | sc-490136 | 5 mg | $290.00 | ||
GSK923295 is a selective inhibitor of CENP-E motor activity. This inhibition leads to defects in mitotic chromosome alignment, a cellular process that requires the function of Klp3. By inhibiting CENP-E, GSK923295 indirectly inhibits Klp3 by disrupting the proper formation and function of the mitotic spindle. | ||||||
Reversine | 656820-32-5 | sc-203236 | 5 mg | $221.00 | 13 | |
Reversine is a small molecule that acts as an Aurora kinase inhibitor, and also impacts other kinases involved in mitotic spindle formation. By inhibiting Aurora kinase, Reversine indirectly inhibits Klp3 by disrupting spindle assembly and function, which are crucial for Klp3's role in cell division. | ||||||