KIAA1913 Inhibitors
Chemical inhibitors of KIAA1913 target various aspects of the protein's function and its cellular context. Wortmannin and LY294002 are phosphoinositide 3-kinase (PI3K) inhibitors that can disrupt membrane trafficking and protein localization, which are crucial for KIAA1913 activity. By hindering PI3K-mediated signaling, these inhibitors may prevent KIAA1913 from reaching or maintaining its position in the plasma membrane, thus inhibiting its function. Brefeldin A, by dismantling the Golgi apparatus structure, can also impair the trafficking of KIAA1913, ensuring it does not reach its functional locale within the cell. This disruption of Golgi function is a critical step in the protein maturation and trafficking pathway that would be necessary for KIAA1913's activity.
Furthermore, the endocytic pathway inhibitor Dynasore can inhibit the function of KIAA1913 by halting its internalization, which could be essential for its recycling or degradation, thereby affecting the protein's turnover and regulation. Genistein interrupts tyrosine kinase-mediated pathways, which can inhibit KIAA1913 if its function is contingent on tyrosine phosphorylation. U73122, a phospholipase C inhibitor, can alter the phospholipid signaling that may be necessary for KIAA1913's activation or stabilization. Inhibitors like PD 98059 and SB203580, which target the MEK/ERK and p38 MAPK pathways respectively, can impede signaling cascades that regulate KIAA1913, while SP600125's inhibition of JNK signaling can disrupt regulatory pathways that may control KIAA1913's cellular functions. Y-27632, a ROCK inhibitor, can modify the cytoskeletal organization and membrane-associated processes that may govern the function of KIAA1913. Gö 6983's inhibition of protein kinase C (PKC) and PP2's inhibition of Src family kinases can dismantle other possible regulatory pathways that control the KIAA1913's activity, further substantiating their roles as functional inhibitors of the protein.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent phosphoinositide 3-kinase (PI3K) inhibitor. Given that KIAA1913 is a transmembrane protein, its function could be dependent on PI3K-mediated signaling. Inhibition of PI3K can disrupt membrane trafficking and protein localization, potentially inhibiting KIAA1913 function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts Golgi apparatus structure and function, which could inhibit KIAA1913 by interfering with its proper trafficking to the plasma membrane, where it may exert its function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits dynamin, a GTPase required for endocytosis. Inhibition of endocytosis could prevent internalization of KIAA1913, disrupting its recycling or degradation processes and inhibiting its function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. If KIAA1913 function is regulated by tyrosine phosphorylation, genistein could inhibit its activity by preventing this post-translational modification. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor. By inhibiting PI3K, LY294002 could disrupt membrane protein trafficking or signaling pathways that are critical for the functional activity of KIAA1913. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a MEK inhibitor that prevents the activation of ERK/MAPK pathway. As such, it could inhibit KIAA1913 function by altering intracellular signaling cascades that regulate its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. If KIAA1913 activity is regulated through p38 MAPK-dependent signaling pathways, this compound could inhibit the protein's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, it could disrupt pathways that regulate KIAA1913's cellular localization or function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor. By inhibiting the Rho-associated protein kinase, it could alter the cytoskeletal dynamics and membrane-associated processes that possibly regulate KIAA1913 function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a broad-spectrum protein kinase C inhibitor. If KIAA1913 function is regulated by PKC-mediated pathways, inhibition of PKC could result in the functional inhibition of KIAA1913. | ||||||