KIAA1467 Inhibitors

Direct inhibitors of KIAA1467 interact directly with the protein and reduce its expression or activity. These include chemicals that can block the binding of KIAA1467 to its binding partners, reduce the transcription of the KIAA1467 gene, or promote the degradation of the KIAA1467 protein. Examples of direct inhibitors include ICG-003, Chirality-corrected Cyclosporin A (CSA), and SMI-16a. SMI-16a promotes the interaction between Dishevelled and AXIN proteins, leading to decreased β-catenin stabilization and suppression of KIAA1467 expression.

Indirect inhibitors of KIAA1467 do not directly interact with the protein but instead act on upstream signaling pathways or cellular processes that can influence KIAA1467 expression or degradation. These include chemicals that can activate or inhibit signaling pathways, modulate protein stability or degradation, or alter cellular processes such as oxidative stress or inflammation. Examples of indirect inhibitors include, Phorbol 12-myristate-13-acetate (PMA), Tumor necrosis factor-alpha (TNF-α), and Interleukin-1α (IL-1α). TB509 generates reactive oxygen species (ROS) and activates oxidative stress signaling pathways, promoting KIAA1467 degradation. PMA activates PKC, a signaling molecule that promotes KIAA1467 degradation through phosphorylation-mediated proteasomal targeting. TNF-α and IL-1α induce NF-κB activation, leading to increased KIAA1467 expression. Inhibiting TNF-α and IL-α can indirectly suppress KIAA1467 expression.