KIAA0664 Inhibitors
KIAA0664 inhibitors are a category of chemical agents tailored to specifically engage with and obstruct the activity of the protein expressed by the KIAA0664 gene. The KIAA0664 gene is identified by its genetic designation, which does not immediately convey its biological role, but the gene product is known to be involved in a variety of cellular mechanisms. These inhibitors act by binding to the KIAA0664 protein, thereby altering its normal function. This action can be achieved through different types of inhibition, such as competitive, where the inhibitor molecules vie with the natural substrate for binding sites, or non-competitive, where the inhibitor attaches to a different site on the protein and induces a conformational change that affects the protein's activity. The specific interaction between KIAA0664 inhibitors and their target depends on the molecular structure of both the protein and the inhibitor.
The discovery and refinement of KIAA0664 inhibitors necessitate a deep comprehension of the protein's three-dimensional conformation and the pivotal regions critical for its activity. This class of inhibitors is often uncovered and honed using methods like high-throughput screening, where vast compound libraries are evaluated for their ability to bind to the KIAA0664 protein. Further, structural modifications are performed to improve these compounds' selectivity and potency. Computational techniques such as molecular docking and dynamic simulations also play a significant role, offering detailed insights into how these molecules interact with the KIAA0664 protein at an atomic level, thus guiding the creation of more effective inhibitors. Ensuring that KIAA0664 inhibitors are highly specific is of paramount importance as it helps to minimize unintended interactions with other proteins within the complex biological milieu.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in various cellular processes including growth, proliferation, and survival. By inhibiting PI3K, Wortmannin can indirectly lead to the inhibition of downstream effectors, potentially affecting KIAA0664 if it is functionally connected to PI3K signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another specific inhibitor of PI3K, reducing the phosphorylation of AKT, a downstream target of PI3K. This chemical could thus decrease the activity of KIAA0664 if it is part of the PI3K/AKT signaling axis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mechanistic target of rapamycin (mTOR), a key kinase that regulates protein synthesis and cell growth. If KIAA0664 is regulated by or involved in signaling pathways downstream of mTOR, Rapamycin could lead to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase, which is implicated in inflammatory responses and cellular stress. Inhibition of p38 MAPK could affect KIAA0664 activity if it is involved in cellular responses to stress or inflammation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that blocks the activation of ERK1/2, components of the MAPK/ERK pathway. If KIAA0664 function is linked to the MAPK/ERK pathway, PD98059 could indirectly inhibit its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that prevents the activation of MAPK/ERK signaling. It could potentially inhibit KIAA0664 if the protein operates within this pathway or is regulated by it. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which participates in apoptosis and cell differentiation. KIAA0664 could be affected by SP600125 if it is associated with pathways involving JNK. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
NSC23766 inhibits Rac1, a small GTPase involved in actin cytoskeleton reorganization. If KIAA0664 has a role in processes governed by Rac1, such as cell migration or adhesion, NSC23766 could lead to its inhibition. | ||||||
BAY 11-7085 | 196309-76-9 | sc-202490 sc-202490A | 10 mg 50 mg | $122.00 $516.00 | 55 | |
BAY 11-7085 is an inhibitor of NF-κB activation, which plays a role in immune and inflammatory responses. If KIAA0664 is regulated by NF-κB or is part of NF-κB mediated signaling, its activity might be inhibited by BAY 11-7085. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK), which is involved in regulating cell shape, motility, and contraction. If KIAA0664's function is connected to pathways regulated by ROCK, Y-27632 could indirectly inhibit its activity. | ||||||