KCTD2 Activators
Forskolin empowers the adenylyl cyclase-cAMP pathway, bolstering intracellular signals that lead to the phosphorylation of various proteins. Its counterpart, H-89, offers a contrasting approach by obstructing protein kinase A, suggesting an indirect influence on KCTD2 by altering phosphorylation dynamics. W-7 disrupt calcium signaling, a critical regulator of numerous cellular functions, which could cascade down to affect KCTD2 activity. These antagonists share the stage with Ionomycin, which elevates intracellular calcium levels, potentially impacting calcium-dependent processes and proteins associated with KCTD2.
Okadaic Acid, with its inhibitory action on protein phosphatases, disrupts the delicate equilibrium of phosphorylation within cells, offering a backdoor to influence KCTD2's regulation. Genistein and Staurosporine take a broader approach, targeting tyrosine kinases and protein kinases, respectively, and thereby modifying the signaling landscape in which KCTD2 operates. cAMP analogs like 8-Br-cAMP, by mimicking endogenous signaling molecules, activate protein kinase A and consequentially could alter the modulation of KCTD2. Kinase activity is further scrutinized by compounds such as KN-93, PD98059, LY294002, and SB203580, each selectively inhibiting Ca2+/calmodulin-dependent protein kinases, MEK, PI3K, and p38 MAP kinase, respectively. These inhibitors, by dampening specific pathways, create a ripple effect that can extend to the activity of KCTD2.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Stimulates adenylyl cyclase to increase intracellular cAMP levels, which can lead to changes in phosphorylation patterns affecting proteins like KCTD2. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
Inhibits protein kinase A, which can alter phosphorylation cascades and potentially modulate KCTD2 function. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
Disrupts calmodulin signaling which can change calcium-dependent processes, possibly influencing KCTD2's activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Inhibits protein phosphatases PP1 and PP2A, altering phosphorylation states, which could impact KCTD2 indirectly. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Inhibits tyrosine kinases, which could modify phosphorylation patterns and indirectly affect KCTD2 function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent protein kinase inhibitor, which can affect multiple signaling pathways and potentially KCTD2's activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
A cAMP analog that can activate PKA and modulate phosphorylation processes, potentially influencing KCTD2. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Increases intracellular calcium, which can activate calcium-dependent proteins and pathways possibly affecting KCTD2. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
Inhibits Ca2+/calmodulin-dependent protein kinase II, which could alter signaling pathways involving KCTD2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, which could change ERK pathway activity and potentially modulate KCTD2 indirectly. | ||||||