KBTBD11 Activators
KBTBD11 activators represent a class of compounds that influence various cellular signaling pathways and processes, which in turn can affect the functional activity of KBTBD11. Forskolin, by increasing intracellular cAMP levels, activates PKA, which can phosphorylate proteins that may be critical to the function of KBTBD11. This phosphorylation can lead to an enhancement of KBTBD11's role in ubiquitination processes, potentially affecting protein turnover. Compounds like Epigallocatechin gallate and Okadaic Acid modulate the phosphorylation status of cellular proteins by inhibiting phosphatases, thereby potentially altering the signaling environment to favor KBTBD11's activity.
Other compounds such as PMA and IBMX affect protein kinase C and phosphodiesterase activity, respectively, leading to the modulation of signaling networks that could result in the enhancement of KBTBD11'sactivity. PMA's activation of PKC could lead to a cascade of phosphorylation events that bolster KBTBD11's interactions with other proteins, possibly enhancing its ubiquitination capacity. Likewise, IBMX's elevation of cAMP and cGMP levels may amplify PKA or PKG pathways, which can indirectly influence the functional dynamics of KBTBD11.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an adenylate cyclase activator that increases intracellular cAMP levels. Elevated cAMP enhances the PKA signaling pathway, which can lead to phosphorylation of proteins that interact with KBTBD11, enhancing its functional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate is a polyphenol found in green tea that inhibits the activity of certain phosphatases. Inhibition of these phosphatases can lead to sustained activation of signaling proteins that may act as co-factors for KBTBD11. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells, which can enhance PKA or PKG pathways respectively, potentially enhancing the activity of KBTBD11. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a diacylglycerol analog that activates protein kinase C (PKC), which can phosphorylate substrates that may regulate KBTBD11's stability or interaction with other proteins. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, which can lead to increased phosphorylation of cellular proteins. This could enhance signaling pathways that indirectly increase the functional activity of KBTBD11. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which can alter the AKT signaling pathway. Despite being an inhibitor, it can cause compensatory responses in cellular signaling that could enhance pathways involving KBTBD11. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that could lead to alteration in stress response pathways, potentially affecting protein interactions and enhancing the functional activity of KBTBD11. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which may lead to changes in cellular stress and apoptotic signaling pathways. This could indirectly enhance pathways or protein-protein interactions involving KBTBD11. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor that can affect cytoskeletal dynamics. Changes in cytoskeletal organization can influence the activity of numerous proteins, including KBTBD11, by altering its protein interactions. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor leading to increased cytosolic calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, which might enhance the functional activity of KBTBD11. | ||||||