karyopherin α Activators
Karyopherin α is a type of protein that is integral to the nuclear transport process, which is the mechanism by which molecules are shuttled between the cytoplasm and the nucleus of a cell. Karyopherins are part of the superfamily of proteins that mediate nucleocytoplasmic transport, recognizing and binding to nuclear localization signals (NLS) on cargo proteins, subsequently recruiting karyopherin β (importin β) to form a complex that can traverse the nuclear pore complex (NPC).
Karyopherin α activators are a class of chemicals that can modulate this transport process by enhancing the ability of karyopherin α to recognize, bind, or transport cargo proteins. These activators can directly facilitate the interaction between karyopherin α and its cargo by stabilizing the binding interface or inducing conformational changes that increase the affinity of karyopherin α for NLS-containing proteins. Alternatively, activators may increase the efficiency of the translocation process by promoting the interaction between the karyopherin α-cargo complex and karyopherin β, optimizing the formation of the ternary complex necessary for successful nuclear import. Indirect activators might influence the expression levels of karyopherin α, leading to an increase in the cellular concentration of the protein and potentially a higher rate of nuclear import. Other indirect mechanisms could involve the modulation of post-translational modifications of karyopherin α, such as phosphorylation or ubiquitination, which can regulate its activity, localization, or interaction with cargo proteins and karyopherin β.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting the PI3K/Akt pathway, it indirectly impacts karyopherin α, since this pathway controls various aspects of cell survival and growth, including nuclear import mechanisms. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can indirectly modulate karyopherin α by inhibiting tyrosine kinases, which are involved in the regulation of nuclear transport. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that can indirectly modulate karyopherin α by suppressing the MAPK pathway, which plays a critical role in controlling nuclear import-export mechanisms. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor. By inhibiting the PI3K/Akt pathway, it indirectly affects karyopherin α, since this pathway is involved in various cellular processes including nuclear transport. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can indirectly modulate karyopherin α by suppressing the p38 MAPK pathway, which is involved in the regulation of nuclear transport. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that can indirectly modulate karyopherin α by suppressing the JNK pathway, which has a part in the regulation of nuclear import-export mechanisms. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, can indirectly affect karyopherin α by inhibiting the mTOR pathway, which is known to control various aspects of cell growth and survival, including nuclear import mechanisms. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG490 is a JAK2 inhibitor that can indirectly modulate karyopherin α by suppressing the JAK-STAT pathway. This pathway is involved in various cellular processes, including the regulation of nuclear transport. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an IκBα phosphorylation inhibitor that can indirectly modulate karyopherin α by suppressing the NF-κB pathway, which plays a part in controlling nuclear import-export mechanisms. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a Src inhibitor that can indirectly affect karyopherin α by inhibiting Src tyrosine kinases, which are involved in various cellular processes, including the regulation of nuclear import. | ||||||