JIP-2 Inhibitors
JIP-2 inhibitors belong to a class of chemical compounds that specifically target the c-Jun N-terminal kinase (JNK)-interacting protein 2 (JIP-2). JIP-2 is a scaffolding protein that plays a crucial role in regulating the signaling pathways associated with the mitogen-activated protein kinase (MAPK) family, particularly the JNK pathway. The JNK pathway is a key mediator of cellular responses to various stress stimuli and is implicated in processes such as apoptosis, inflammation, and differentiation. By inhibiting JIP-2, these compounds modulate the downstream signaling cascades mediated by JNK, thereby influencing cellular behaviors and responses.
JIP-2 inhibitors is designed to interact specifically with the binding sites on JIP-2, disrupting its ability to facilitate the activation of JNK. The inhibition of JIP-2 prevents the proper assembly and activation of the JNK signaling complex, leading to a downstream attenuation of cellular responses associated with this pathway. The development of JIP-2 inhibitors has been driven by the need to dissect the intricate molecular mechanisms underlying JNK-mediated signaling and to gain insights into the physiological and pathological processes governed by this pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an anthrapyrazolone inhibitor that can inhibit JNK, thereby modulating the activity of downstream proteins including MAPK8IP2. By inhibiting JNK, it prevents the phosphorylation of c-Jun and the subsequent activation of transcription factors that are involved in cell proliferation and apoptosis. | ||||||
JNK Inhibitor V | 345987-15-7 | sc-202672A sc-202672 | 1 mg 5 mg | $60.00 $169.00 | 3 | |
JNK Inhibitor V is a pyrrolopyrazole derivative that can inhibit JNK activity. This inhibition can impact the JNK signaling pathway and subsequently influence the proteins interacting with this pathway, such as MAPK8IP2. | ||||||
JNK Inhibitor XVI | 1410880-22-6 | sc-364745 | 10 mg | $357.00 | 5 | |
JNK Inhibitor XVI is a selective JNK inhibitor known to covalently bind to cysteine residues near the ATP binding site of JNK. This binding can lead to reduced phosphorylation of JNK substrates, including those associated with MAPK8IP2. | ||||||
BI 78D3 | 883065-90-5 | sc-203840 sc-203840A | 10 mg 50 mg | $204.00 $810.00 | 2 | |
BI-78D3 functions as a competitive inhibitor of JIP1 (JNK Interacting Protein 1), which is a scaffold protein for JNK, closely related to MAPK8IP2. By disrupting JIP1 function, it can indirectly affect JNK signaling and thus MAPK8IP2. | ||||||
IQ-1 | 331001-62-8 | sc-202665 | 10 mg | $180.00 | 2 | |
This selective JNK3 inhibitor binds to the ATP-binding site of JNK3, leading to reduced kinase activity. Although JNK3 is not identical to JNK1/2, often associated with MAPK8IP2, its inhibition can still influence the broader JNK pathway and proteins interacting with it. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound with known inhibitory effects on the JNK pathway. By modulating JNK signaling, it can alter the function of proteins that are regulated by this pathway, including MAPK8IP2. | ||||||
CC-401 | 395104-30-0 | sc-364748 sc-364748A | 2 mg 10 mg | $331.00 $1060.00 | 4 | |
CC-401 is a second-generation JNK inhibitor with potential to alter JNK-mediated phosphorylation events, which can influence the interaction and function of MAPK8IP2. | ||||||