Ivl Inhibitors
IVL inhibitors belong to a class of compounds that are specifically designed to inhibit the activity of the enzyme Involucrin (IVL), a protein expressed in the upper layers of the epidermis. Involucrin plays a key role in the formation of the cornified cell envelope by serving as a substrate for transglutaminases, which cross-link proteins to form a tough, protective barrier. IVL inhibitors work by blocking this protein's function, thereby modulating processes involved in the formation and stability of the skin barrier. These inhibitors are often used in research settings to study skin physiology, particularly the regulation of epidermal differentiation and cornification processes.
Chemically, IVL inhibitors vary widely in their structural frameworks, but many share key functional groups capable of interacting with IVL's active sites. These inhibitors often rely on specific molecular scaffolds that can disrupt the protein's function either by competitive binding or through allosteric mechanisms. Researchers have developed different types of IVL inhibitors, each fine-tuned to target distinct regions of the protein or to exhibit varying degrees of potency and selectivity. These compounds are valuable tools in understanding the biochemical pathways regulating the outermost layer of the skin, shedding light on how protein cross-linking and barrier formation are controlled at the molecular level. The study of IVL inhibitors can also provide insights into broader mechanisms of protein cross-linking, protein degradation, and epidermal homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may inhibit involucrin expression by modulating the retinoic acid receptor signaling pathway, leading to altered gene expression and downregulation of genes involved in keratinocyte differentiation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin exhibits inhibitory effects on involucrin expression possibly through modulation of signaling pathways such as NF-κB, which regulates genes involved in keratinocyte differentiation and epidermal homeostasis. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane may inhibit involucrin expression by activating Nrf2 signaling, which regulates the expression of genes involved in keratinocyte differentiation and epidermal barrier function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol might inhibit involucrin expression by modulating the SIRT1/AMPK pathway, leading to alterations in gene expression patterns related to keratinocyte differentiation and epidermal integrity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin may inhibit involucrin expression through its antioxidant properties and ability to modulate signaling pathways such as MAPK and PI3K/Akt, which regulate keratinocyte differentiation processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG could potentially inhibit involucrin expression by interfering with the activity of transcription factors like AP-1 and NF-κB, which regulate genes involved in keratinocyte differentiation and epidermal function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein may inhibit involucrin expression by modulating the estrogen receptor signaling pathway, leading to alterations in gene expression patterns associated with keratinocyte differentiation and epidermal function. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein might inhibit involucrin expression through inhibition of STAT3 signaling, which regulates genes involved in keratinocyte differentiation and epidermal homeostasis. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $56.00 $180.00 | 8 | |
Ursolic acid could potentially inhibit involucrin expression by modulating the activity of transcription factors like AP-1 and Sp1, which regulate genes involved in keratinocyte differentiation and epidermal function. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol exhibits potential inhibitory effects on involucrin expression possibly through modulation of signaling pathways such as PI3K/Akt, which regulate genes involved in keratinocyte differentiation and epidermal homeostasis. | ||||||