ITF Activators
The class of ITF activators comprises a diverse array of chemicals that intricately modulate the activity of ITF, a protein involved in various cellular processes. One key member of this class is 2-Arachidonoylglycerol, a direct activator that acts as an endocannabinoid, binding to cannabinoid receptors CB1 and CB2. This binding triggers downstream signaling, including the MAPK pathway, leading to the activation of ITF. 2-Arachidonoylglycerol exemplifies how endocannabinoids play a crucial role in modulating ITF activity through specific receptor-mediated pathways, emphasizing the intricate interplay between lipid signaling and ITF activation. Forskolin, an indirect activator, stimulates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates protein kinase A (PKA), which then modulates the MAPK pathway, resulting in the activation of ITF. This chemical illustrates how cyclic nucleotide signaling pathways can indirectly influence ITF activity, highlighting the importance of intracellular signaling cascades in the regulation of ITF activation.
Additionally, PMA (Phorbol 12-myristate acetate) serves as a direct activator of ITF by activating protein kinase C (PKC) through its diacylglycerol mimicking. Activated PKC phosphorylates and activates ITF, showcasing the direct modulation of ITF through PKC-dependent pathways. This emphasizes the significance of diacylglycerol-mediated signaling in the regulation of ITF activation. Retinoic acid, another indirect activator, modulates the retinoic acid receptor (RAR) signaling pathway, leading to the activation of ITF. This chemical provides insights into how nuclear receptor-mediated pathways, influenced by compounds like retinoic acid, can indirectly impact ITF activity, highlighting the connection between cellular signaling and the regulation of ITF expression and function. These examples collectively underscore the diverse mechanisms by which chemicals can modulate ITF, ranging from direct activation through receptor-mediated pathways to indirect modulation via intracellular signaling cascades. Understanding these interactions provides valuable insights into the complex regulatory network governing ITF activity and its potential implications in various cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin indirectly activates ITF by stimulating adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates protein kinase A (PKA), which subsequently modulates the MAPK pathway, resulting in the activation of ITF. This chemical provides insight into how cAMP-dependent signaling pathways can indirectly influence ITF activity, emphasizing the importance of cyclic nucleotide signaling in the regulation of ITF activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA serves as a direct activator of ITF by activating protein kinase C (PKC) through its mimicking of diacylglycerol. Activated PKC then phosphorylates and activates ITF, leading to increased cellular responses. This chemical exemplifies the direct modulation of ITF through PKC-dependent pathways, underscoring the significance of diacylglycerol-mediated signaling in the regulation of ITF activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid indirectly activates ITF by modulating the retinoic acid receptor (RAR) signaling pathway. Upon binding to RAR, it triggers transcriptional events that lead to the activation of ITF. This chemical illustrates the connection between retinoic acid signaling and ITF activation, emphasizing the role of nuclear receptor-mediated pathways in the regulation of ITF expression and function. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine acts as a direct activator of ITF by binding to adrenergic receptors, particularly β-adrenergic receptors. This activation triggers the cAMP-PKA pathway, leading to the phosphorylation and activation of ITF. Epinephrine showcases how activation of adrenergic receptors can directly modulate ITF through signaling cascades, emphasizing the role of neurotransmitter signaling in the regulation of ITF activity. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
Retinol, or Vitamin A, indirectly activates ITF by serving as a precursor for retinoic acid synthesis. Through conversion to retinoic acid, it modulates the retinoic acid receptor (RAR) signaling pathway, leading to the activation of ITF. This chemical provides insights into how nutritional factors, such as retinol, can indirectly influence ITF activity, highlighting the connection between dietary components and the regulation of ITF expression and function. | ||||||
Oxotremorine M | 63939-65-1 | sc-203656 | 100 mg | $148.00 | 3 | |
Oxo-M acts as a direct activator of ITF by binding to muscarinic acetylcholine receptors (M receptors). Upon activation, these receptors trigger intracellular signaling cascades, including the MAPK pathway, leading to the activation of ITF. Oxo-M exemplifies the direct modulation of ITF through muscarinic acetylcholine receptors, underscoring the significance of cholinergic signaling in the regulation of ITF activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol serves as a direct activator of ITF by binding to β-adrenergic receptors. Activation of these receptors triggers the cAMP-PKA pathway, leading to the phosphorylation and activation of ITF. Isoproterenol showcases how stimulation of adrenergic receptors can directly modulate ITF through signaling cascades, emphasizing the role of neurotransmitter signaling in the regulation of ITF activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a direct activator of ITF by facilitating calcium influx into cells. Increased intracellular calcium levels activate calmodulin-dependent pathways, including the MAPK pathway, leading to the activation of ITF. A23187 exemplifies the direct modulation of ITF through calcium-dependent signaling, underscoring the significance of calcium-mediated pathways in the regulation of ITF activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin serves as a direct activator of ITF by inducing calcium influx into cells. Elevated intracellular calcium levels activate calmodulin-dependent pathways, including the MAPK pathway, leading to the activation of ITF. Ionomycin illustrates the direct modulation of ITF through calcium-dependent signaling, emphasizing the importance of calcium-mediated pathways in the regulation of ITF activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP indirectly activates ITF by serving as a cell-permeable cAMP analog. Increased intracellular cAMP levels activate protein kinase A (PKA), which subsequently modulates the MAPK pathway, resulting in the activation of ITF. This chemical provides insights into how cAMP-dependent signaling pathways can indirectly influence ITF activity, emphasizing the importance of cyclic nucleotide signaling in the regulation of ITF activation. | ||||||