IPP-1 Activators
IPP-1, also known as protein phosphatase 1 inhibitor-1, exerts significant regulatory control over cellular processes by modulating the activity of protein phosphatase 1 (PP1). PP1, a key serine/threonine phosphatase, plays a pivotal role in various cellular pathways by catalyzing the dephosphorylation of a diverse array of substrates. IPP-1 functions as an endogenous inhibitor of PP1, tightly regulating its activity and thereby influencing critical cellular functions such as glycogen metabolism, cardiac contractility, and synaptic plasticity. Through its interaction with PP1, IPP-1 serves as a key component of cellular signaling networks, fine-tuning phosphorylation-dependent signaling events and maintaining cellular homeostasis.
Activation of IPP-1 involves complex regulatory mechanisms aimed at enhancing its inhibitory activity towards PP1 and modulating downstream cellular responses. Several factors contribute to the activation of IPP-1, including post-translational modifications, intracellular signaling pathways, and protein-protein interactions. Phosphorylation of IPP-1 at specific sites has been shown to enhance its inhibitory potency towards PP1, thereby increasing the blockade of substrate dephosphorylation and influencing cellular signaling cascades. Additionally, cellular stimuli can trigger signaling pathways that regulate IPP-1 activity, providing dynamic control over PP1-mediated dephosphorylation events in response to environmental cues. Understanding the mechanisms underlying IPP-1 activation offers insights into the regulation of PP1 activity and its implications for cellular physiology and signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride activates IPP-1 indirectly by inhibiting GSK-3β, a negative regulator of IPP-1. By preventing GSK-3β-mediated degradation of IPP-1, lithium chloride promotes its stability and availability for participation in cellular processes dependent on IPP-1-mediated dephosphorylation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates IPP-1 by stimulating adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates PKA, which in turn phosphorylates IPP-1 and enhances its catalytic activity, promoting cellular processes reliant on IPP-1-mediated dephosphorylation events. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 activates IPP-1 by inhibiting ROCK, a kinase that negatively regulates IPP-1. By preventing ROCK-mediated inhibition, Y-27632 enhances IPP-1 activity, influencing cellular processes through its role in dephosphorylation events. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate activates IPP-1 by inhibiting tyrosine phosphatases. This inhibition leads to sustained phosphorylation of IPP-1, enhancing its activity in cellular processes dependent on IPP-1-mediated dephosphorylation, such as the regulation of key signaling pathways. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720 activates IPP-1 by inhibiting PP2A. Through the disruption of PP2A function, FTY720 enhances IPP-1 activity, leading to modulation of cellular processes dependent on IPP-1-mediated dephosphorylation, providing a potential avenue for the precise regulation of IPP-1. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride activates IPP-1 by inhibiting serine/threonine phosphatases. By disrupting the activity of these phosphatases, sodium fluoride sustains IPP-1 phosphorylation, enhancing its activity and contributing to the modulation of cellular processes governed by IPP-1-mediated dephosphorylation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I activates IPP-1 by inhibiting PKC, a kinase that negatively regulates IPP-1. Through PKC inhibition, bisindolylmaleimide I promotes IPP-1 activity, influencing cellular processes reliant on IPP-1-mediated dephosphorylation, providing a targeted approach for modulating IPP-1 functions. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
NSC23766 activates IPP-1 indirectly by inhibiting Rac1, a negative regulator of IPP-1 function. Reduced Rac1 activity enhances IPP-1's involvement in signaling pathways related to cellular processes, offering an alternative approach to modulate IPP-1 activity indirectly. | ||||||
Diosgenin | 512-04-9 | sc-205652 sc-205652B sc-205652A | 5 g 25 g 100 g | $46.00 $128.00 $507.00 | 4 | |
Diosgenin activates IPP-1 by inhibiting GSK-3β, a kinase that negatively regulates IPP-1. By preventing GSK-3β-mediated degradation of IPP-1, diosgenin promotes its stability and availability for participation in cellular processes dependent on IPP-1-mediated dephosphorylation, offering a targeted approach for modulating IPP-1 functions. | ||||||