INTS3 Activators
INTS3 Activators would comprise a class of chemicals that modulate the activity of Integrator complex subunit 3 indirectly by influencing cellular mechanisms that regulate the expression or stability of the protein. The transcription and subsequent synthesis of the INTS3 protein can be upregulated through the action of chemicals that modify the chromatin state, such as 5-Azacytidine and histone deacetylase inhibitors like Trichostatin A, SAHA, and Sodium Butyrate. These compounds can activate INTS3 by reducing DNA methylation levels or increasing histone acetylation at the INTS3 gene locus, which loosens chromatin structure and promotes transcription factor access. Hormone-like signals, including retinoic acid and beta-estradiol, exert their effects by interacting with their respective receptors, which bind to the INTS3 gene's regulatory regions, enhancing its expression.
On the other hand, stabilization of the INTS3 protein and prevention of its degradation also serve as activation mechanisms. Compounds like Disulfiram and MG132 block the proteasomal degradation pathway, while Chloroquine disrupts lysosomal degradation through autophagy inhibition, leading to an accumulation of the INTS3 protein within the cell. Lithium Chloride and Rapamycin act on upstream kinases like GSK-3 and signaling pathways like mTOR, respectively, which can modify the turnover and synthesis of INTS3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine can lead to hypomethylation of the INTS3 gene promoter, facilitating its transcription by permitting transcription factor binding and chromatin expansion. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylase, enhancing acetylation of histones near the INTS3 gene, thereby relaxing chromatin and increasing transcriptional activity to raise INTS3 levels. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors which can directly bind to the regulatory regions of the INTS3 gene, enhancing its transcription and thereby raising the levels of the INTS3 protein. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Beta-estradiol interacts with estrogen receptors that can bind to estrogen-responsive elements on the INTS3 gene promoter, promoting its transcription and increasing INTS3 protein synthesis. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 binds to the bromodomains of BET proteins, displacing them from chromatin, which can result in the upregulation of INTS3 gene transcription if BET proteins were repressing the INTS3 locus. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit the proteasomal degradation pathway, potentially leading to reduced degradation of INTS3 and an increase in its intracellular levels. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 inhibits the proteasome, leading to decreased degradation of many proteins, including possibly the INTS3 protein, thereby increasing its cellular concentration. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, which may reduce phosphorylation-dependent degradation of INTS3, leading to its accumulation in the cell. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA inhibits histone deacetylases, which can increase acetylation levels of histones associated with the INTS3 gene, promoting its transcription and increasing INTS3 protein levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which can lead to de-repression of transcriptional programs that are suppressed by mTOR, potentially including the INTS3 gene, thereby increasing INTS3 protein synthesis. | ||||||