Intersectin Inhibitors
Intersectin inhibitors belong to a specific class of chemical compounds that are designed to modulate the activity of intersectin proteins within biological systems. Intersectins are a family of multidomain scaffolding proteins that play a crucial role in cellular processes, particularly in the regulation of endocytosis and cytoskeletal dynamics. These proteins are characterized by their ability to interact with various cellular partners and to serve as molecular hubs that coordinate complex cellular signaling events. Intersectin inhibitors are molecular entities designed to interfere with the functions of these proteins, either by blocking their binding sites or by disrupting their interactions with other cellular components.
The development and study of intersectin inhibitors have primarily stemmed from the recognition of intersectins' central role in cellular processes. Researchers have synthesized a variety of small molecules and compounds that can selectively target intersectins, aiming to elucidate their precise roles in cellular signaling pathways and potentially uncover new insights into fundamental cellular biology. By inhibiting intersectin activity, these compounds allow scientists to manipulate the intricate processes of endocytosis and cytoskeletal dynamics, shedding light on the molecular mechanisms underlying these essential cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3 inhibits cytohesins, which are guanine nucleotide exchange factors (GEFs) for ADP-ribosylation factors (ARFs). Intersectin acts as a scaffold for cytohesins; hence, inhibiting cytohesins can interfere with Intersectin-associated signaling pathways. | ||||||
Hydroxy-Dynasore | 1256493-34-1 | sc-364678 | 10 mg | $255.00 | ||
Dyngo-4a blocks the uncoating of clathrin-coated vesicles. Since Intersectin participates in the assembly of clathrin-coated pits, this compound can indirectly inhibit Intersectin's role in endocytosis. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a GTPase inhibitor that specifically targets dynamin, which is crucial for the scission of clathrin-coated vesicles. Intersectin interacts with dynamin; thus, Dynasore can alter Intersectin's ability to regulate endocytosis. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT 1864 is a Rac1 inhibitor. Rac1 is a small GTPase that can interact with Intersectin. By inhibiting Rac1, EHT 1864 can indirectly modulate the functions of Intersectin that are dependent on Rac1 activity. | ||||||
Dynole 34-2 | 1128165-88-7 | sc-362731 sc-362731A | 10 mg 50 mg | $205.00 $849.00 | ||
Iminodyn-22 inhibits dynamin, thus affecting clathrin-mediated endocytosis. Since Intersectin is involved in this process, Iminodyn-22 can indirectly disrupt its activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus and interferes with ARF-dependent processes. Given Intersectin's interaction with ARF6, Brefeldin A can indirectly affect Intersectin-mediated signaling. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Gö6976 is a protein kinase C inhibitor. While not directly inhibiting Intersectin, it can influence downstream signaling that may involve Intersectin's scaffold functions. | ||||||