Hydroxy-Dynasore (CAS 1256493-34-1)
Alternate Names:
Dynamin Inhibitor IV; 3-Hydroxynaphthalene-2-carboxylic acid-(2,4,5-trihydroxybenzylidene)-hydrazide; Dyngo-4a
Application:
Hydroxy-Dynasore is an inhibitor of dynamin I and dynamin II
CAS Number:
1256493-34-1
Purity:
≥97%
Molecular Weight:
338.3
Molecular Formula:
C18H14N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hydroxy-Dynasore is a synthetic small molecule known for its ability to reversibly inhibit dynamin, a GTPase involved in the process of endocytosis and other cellular functions. This compound is a hydroxylated derivative of Dynasore, designed to enhance its potency and selectivity towards its target. By interfering with the dynamin function, it plays a critical role in the modulation of endocytosis, a fundamental cellular process responsible for the internalization of extracellular materials and membrane recycling.
Hydroxy-Dynasore (CAS 1256493-34-1) References
- Structural correlates of rotavirus cell entry. | Abdelhakim, AH., et al. 2014. PLoS Pathog. 10: e1004355. PMID: 25211455
- Balancing spatially regulated β-actin translation and dynamin-mediated endocytosis is required to assemble functional epithelial monolayers. | Cruz, LA., et al. 2015. Cytoskeleton (Hoboken). 72: 597-608. PMID: 26615964
- Photothermal Ablation of in Situ Renal Tumor by PEG-IR780-C13 Micelles and Near-Infrared Irradiation. | Qiu, X., et al. 2016. Mol Pharm. 13: 829-38. PMID: 26713719
- CD36 Differently Regulates Macrophage Responses to Smooth and Rough Lipopolysaccharide. | Biedroń, R., et al. 2016. PLoS One. 11: e0153558. PMID: 27073833
- Interleukin-6 secretion is limited by self-signaling in endosomes. | Verboogen, DRJ., et al. 2019. J Mol Cell Biol. 11: 144-157. PMID: 30016456
- SIV-Mediated Synaptic Dysfunction Is Associated with an Increase in Synapsin Site 1 Phosphorylation and Impaired PP2A Activity. | Shekarabi, M., et al. 2019. J Neurosci. 39: 7006-7018. PMID: 31270156
- The uptake mechanism and intracellular fate of Paraoxonase-1 in endothelial cells. | Raz, BD., et al. 2020. Free Radic Biol Med. 153: 26-33. PMID: 32244050
- Impact of Endocytosis and Lysosomal Acidification on the Toxicity of Copper Oxide Nano- and Microsized Particles: Uptake and Gene Expression Related to Oxidative Stress and the DNA Damage Response. | Strauch, BM., et al. 2020. Nanomaterials (Basel). 10: PMID: 32260290
- Internalization of Polymeric Bacterial Peptidoglycan Occurs through Either Actin or Dynamin Dependent Pathways. | Popescu, NI., et al. 2022. Microorganisms. 10: PMID: 35336127
- Comparing extracellular vesicles and cell membranes as biocompatible coatings for gold nanorods: Implications for targeted theranostics. | Pincela Lins, PM., et al. 2022. Eur J Pharm Biopharm. 176: 168-179. PMID: 35643369
- Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses. | Yang, X., et al. 2022. ACS Chem Biol. 17: 1937-1950. PMID: 35723434
- The amount of dextran in PLGA nanocarriers modulates protein corona and promotes cell membrane damage. | Antonio, LC., et al. 2022. J Mater Chem B. 10: 8282-8294. PMID: 36155711
- Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics. | Park, H., et al. 2022. Nat Commun. 13: 6112. PMID: 36245040
- Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration. | Shirakura, K., et al. 2023. EMBO Mol Med. 15: e16128. PMID: 36740996
- Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression. | Yang, X., et al. 2023. Adv Sci (Weinh). 10: e2207216. PMID: 36951540
Inhibitor of:
1700013F07Rik, ACAP2, ANKFY1, ANKMY1, AP3 Adaptor Complex, Arf2, ARL4, DENND5B, Dynamin I, Dynamin II, Dynamin III, EHD (EH Domain Containing), epsin, epsin2, FCHO2, Intersectin, IntersectinL, IST1, LOC653720, LRRC6, NECAP 2, PACS-1b, PACSIN3, Rab 27b, Rab 33A, Rab 3D, Rab 6, Rab 9B, Rab11-FIP1, Rabenosyn-5, RUFY1, SNX20, Sorting Nexin (SNX), STON1, STON2, Synaptojanin 2, TBC1D3, TTC21B, TULP1, UNC93A, and VPS53.Activator of:
GCC2, NEURL1B, and RAb 19B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hydroxy-Dynasore, 10 mg | sc-364678 | 10 mg | $255.00 |