Integrin βL1 Activators
The chemicals that can influence the activation of integrin βL1, or ITGBL1, are involved in complex cellular signaling pathways including the MAPK, PI3K/AKT/mTOR, and the NF-κB pathways. These chemicals typically modulate specific components of these pathways, leading to a potential increase in ITGBL1 expression. Protein kinase C (PKC) is activated by Phorbol 12-myristate 13-acetate (PMA), leading to the phosphorylation of IKKα/β, triggering IκB proteins degradation and subsequently activating NF-κB.On the other hand, LY294002, Quercetin, and Epigallocatechin gallate (EGCG) inhibit PI3K, a central regulator of the AKT pathway. Inhibition of PI3K decreases AKT phosphorylation, which subsequently modulates the activity of GSK-3β, an inhibitor of NF-κB. Through this mechanism, these PI3K inhibitors can enhance NF-κB activity and thus ITGBL1 expression. mTOR, another critical growth regulator, is inhibited by Rapamycin, and this inhibition can also indirectly increase ITGBL1 expression through crosstalk between mTOR and NF-κB pathways.
Further, the MEK inhibitors U0126 and PD98059 can also increase ITGBL1 expression. MEK is a key component of the MAPK pathway, and its inhibition can enhance the activity of the NF-κB pathway, a known positive regulator of ITGBL1. Additionally, the NF-κB pathway inhibitors BAY 11-7082 and Parthenolide, along with the dual MAPK and NF-κB inhibitor Curcumin, can paradoxically lead to increased ITGBL1 expression in certain contexts. This is due to the complex feedback loops in the NF-κB pathway, where inhibition can sometimes lead to compensatory upregulation of target genes, including ITGBL1. Lastly, Resveratrol and Sulforaphane modulate SIRT1 and Nrf2, respectively. Both of these proteins intersect with NF-κB signaling, and their modulation can influence NF-κB activity and subsequently ITGBL1 expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which influences the downstream signaling pathways, including MAPK and NF-κB. PKC activation can lead to phosphorylation of IKKα/β, triggering the degradation of IκB proteins and subsequent activation of NF-κB. As ITGBL1 is a downstream target of NF-κB, PMA can indirectly enhance ITGBL1 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a central cell growth regulator. mTOR inhibition can increase ITGBL1 expression due to the crosstalk between mTOR and NF-κB pathways. In the absence of mTOR activity, NF-κB can be more active, leading to increased ITGBL1 expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is another MEK inhibitor. Similar to U0126, PD98059's inhibition of MEK can lead to increased ITGBL1 expression by enhancing the activity of the NF-κB pathway. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 irreversibly inhibits IκBα phosphorylation, thereby inhibiting the NF-κB pathway. However, it can paradoxically lead to increased ITGBL1 expression in certain contexts. This is due to the complex feedback loops in the NF-κB pathway, where inhibition can sometimes lead to compensatory upregulation of certain target genes including ITGBL1. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide inhibits NF-κB by preventing IκB degradation. Similar to BAY 11-7082, Parthenolide's inhibition of NF-κB can paradoxically lead to increased ITGBL1 expression in certain contexts. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit both the MAPK and NF-κB pathways. Through this dual inhibition, Curcumin can lead to upregulation of ITGBL1 expression due to compensatory responses in the NF-κB pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can modulate SIRT1, which intersects with NF-κB signaling. By activating SIRT1, Resveratrol can influence NF-κB activity and subsequently ITGBL1 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane can activate Nrf2, a transcription factor that regulates antioxidant response elements. Nrf2 intersects with NF-κB signaling, and its activation can lead to modulated ITGBL1 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin has multiple targets, including inhibition of PI3K. By inhibiting PI3K, Quercetin can enhance NF-κB activity and subsequently ITGBL1 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can inhibit the activity of several kinases, including PI3K. EGCG's inhibition of PI3K can enhance NF-κB activity and subsequently ITGBL1 expression. | ||||||