Date published: 2025-10-23

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INSIG Antibodies

Santa Cruz Biotechnology features a diverse variety of INSIG monoclonal antibodies for advanced research in cellular and molecular biology. INSIG monoclonal antibodies are compatible with multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). INSIG proteins play a crucial role in regulating cholesterol homeostasis and lipid metabolism by interacting with sterol regulatory element-binding proteins (SREBPs). INSIG proteins maintain cellular lipid levels and prevent excessive cholesterol accumulation, which is vital for cellular health and function. Understanding INSIG protein mechanisms can provide insights into metabolic disorders and potential therapeutic targets. Researchers studying lipid metabolism can utilize INSIG monoclonal antibodies to examine protein expression patterns and cellular localization. INSIG monoclonal antibodies enable detailed investigation of protein-protein interactions and regulatory pathways involved in cholesterol metabolism. Santa Cruz Biotechnology monoclonal antibodies for INSIG research support scientists worldwide in advancing our understanding of metabolic regulation and disease mechanisms.

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INSIG Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

INSIG-1 Antibody (A-9)

sc-390504mouse IgG1 κ31-100 (h)WB, IP, IF, IHC(P), ELISAm, r, h
10
(5)

INSIG CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

INSIG-1 CRISPR/Cas9 KO Plasmid (h)

sc-401381hGene KnockoutGFP0
(0)

INSIG-1 HDR Plasmid (h)

sc-401381-HDRhHomology Directed RepairPuromycin0
(0)

INSIG-1 Double Nickase Plasmid (h)

sc-401381-NIChGene KnockoutPuromycin0
(0)

INSIG-1 Double Nickase Plasmid (h2)

sc-401381-NIC-2hGene KnockoutPuromycin0
(0)

INSIG-1 CRISPR/Cas9 KO Plasmid (m)

sc-433033mGene KnockoutGFP0
(0)

INSIG-1 HDR Plasmid (m)

sc-433033-HDRmHomology Directed RepairPuromycin0
(0)

INSIG-1 Double Nickase Plasmid (m)

sc-433033-NICmGene KnockoutPuromycin0
(0)

INSIG-1 Double Nickase Plasmid (m2)

sc-433033-NIC-2mGene KnockoutPuromycin0
(0)

INSIG-2 CRISPR/Cas9 KO Plasmid (h)

sc-402255hGene KnockoutGFP0
(0)

INSIG-2 HDR Plasmid (h)

sc-402255-HDRhHomology Directed RepairPuromycin0
(0)

INSIG-2 Double Nickase Plasmid (h)

sc-402255-NIChGene KnockoutPuromycin0
(0)

INSIG-2 Double Nickase Plasmid (h2)

sc-402255-NIC-2hGene KnockoutPuromycin0
(0)

INSIG-2 CRISPR/Cas9 KO Plasmid (m)

sc-428482mGene KnockoutGFP0
(0)

INSIG-2 HDR Plasmid (m)

sc-428482-HDRmHomology Directed RepairPuromycin0
(0)

INSIG-2 Double Nickase Plasmid (m)

sc-428482-NICmGene KnockoutPuromycin0
(0)

INSIG-2 Double Nickase Plasmid (m2)

sc-428482-NIC-2mGene KnockoutPuromycin0
(0)

INSIG CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

INSIG-1 CRISPR Activation Plasmid (h)

sc-401381-ACThGene ActivationPuro, Blast, Hygro0
(0)

INSIG-1 CRISPR Activation Plasmid (h2)

sc-401381-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

INSIG-1 Lentiviral Activation Particles (h)

sc-401381-LAChGene ActivationPuro, Blast, Hygro0
(0)

INSIG-1 Lentiviral Activation Particles (h2)

sc-401381-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

INSIG-1 CRISPR Activation Plasmid (m)

sc-433033-ACTmGene ActivationPuro, Blast, Hygro0
(0)

INSIG-1 CRISPR Activation Plasmid (m2)

sc-433033-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

INSIG-1 Lentiviral Activation Particles (m)

sc-433033-LACmGene ActivationPuro, Blast, Hygro0
(0)

INSIG-1 Lentiviral Activation Particles (m2)

sc-433033-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

INSIG-2 CRISPR Activation Plasmid (h)

sc-402255-ACThGene ActivationPuro, Blast, Hygro0
(0)

INSIG-2 CRISPR Activation Plasmid (h2)

sc-402255-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

INSIG-2 Lentiviral Activation Particles (h)

sc-402255-LAChGene ActivationPuro, Blast, Hygro0
(0)

INSIG-2 Lentiviral Activation Particles (h2)

sc-402255-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

INSIG-2 CRISPR Activation Plasmid (m)

sc-428482-ACTmGene ActivationPuro, Blast, Hygro0
(0)

INSIG-2 CRISPR Activation Plasmid (m2)

sc-428482-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

INSIG-2 Lentiviral Activation Particles (m)

sc-428482-LACmGene ActivationPuro, Blast, Hygro0
(0)

INSIG-2 Lentiviral Activation Particles (m2)

sc-428482-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

INSIG siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

INSIG-1 siRNA (h)

sc-44432hGene SilencingN/A
4
(0)

INSIG-1 shRNA Plasmid (h)

sc-44432-SHhGene SilencingPuromycin
4
(0)

INSIG-1 shRNA (h) Lentiviral Particles

sc-44432-VhGene SilencingPuromycin
4
(0)

INSIG-1 siRNA (m)

sc-44433mGene SilencingN/A0
(0)

INSIG-1 shRNA Plasmid (m)

sc-44433-SHmGene SilencingPuromycin0
(0)

INSIG-1 shRNA (m) Lentiviral Particles

sc-44433-VmGene SilencingPuromycin0
(0)

INSIG-1 siRNA (r)

sc-270655rGene SilencingN/A0
(0)

INSIG-1 shRNA Plasmid (r)

sc-270655-SHrGene SilencingN/A0
(0)

INSIG-1 shRNA (r) Lentiviral Particles

sc-270655-VrGene SilencingN/A0
(0)

INSIG-2 siRNA (h)

sc-45781hGene SilencingN/A
3
(0)

INSIG-2 shRNA Plasmid (h)

sc-45781-SHhGene SilencingPuromycin
3
(0)

INSIG-2 shRNA (h) Lentiviral Particles

sc-45781-VhGene SilencingPuromycin
3
(0)

INSIG-2 siRNA (m)

sc-45782mGene SilencingN/A0
(0)

INSIG-2 shRNA Plasmid (m)

sc-45782-SHmGene SilencingPuromycin0
(0)

INSIG-2 shRNA (m) Lentiviral Particles

sc-45782-VmGene SilencingPuromycin0
(0)