INPP5F Inhibitors

INPP5F inhibitors belong to a class of chemical compounds designed to target and inhibit the activity of Inositol Polyphosphate-5-Phosphatase F (INPP5F), also known as SKIP. INPP5F is an important phosphatase enzyme that plays a critical role in cellular signaling pathways by regulating the levels of inositol phospholipids. Inositol phospholipids are essential components of cell membranes and are involved in a wide range of cellular processes, including signal transduction, membrane trafficking, and cytoskeleton organization.

INPP5F specifically catalyzes the dephosphorylation of inositol polyphosphate lipids, such as phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) and inositol 1,4,5-trisphosphate (IP3), leading to the generation of inositol bisphosphate lipids and inositol. Inhibitors of INPP5F are developed to interact with this enzyme, potentially disrupting its phosphatase activity and affecting downstream cellular processes regulated by inositol phospholipids.