IFT140 Activators
The chemical class of IFT140 Activators is highly specialized towards affecting the IFT140 protein either directly or through upstream pathways that ultimately have an impact on ciliary function. Many of these activators target specific pathways crucial for ciliogenesis and ciliary signaling, such as the cAMP-PKA pathway influenced by Forskolin and IBMX. The role of cAMP in regulating ciliary length and function puts IFT140 into a position where its activity is crucial for the maintenance of these structures. Moreover, lipid messengers like LPA focus on the G-protein coupled activation that affects intracellular calcium levels, which can further influence the function of IFT140 in ciliogenesis.
Others like Resveratrol and Retinoic Acid provide a unique route of activation by primarily targeting nuclear receptors like SIRT1 or RAR/RXR, which have been associated with ciliogenesis. By influencing these nuclear receptors, a series of downstream events can be triggered, ultimately requiring proper IFT140 function for cilia formation and maintenance. The activators within this class, therefore, represent a diverse set of chemical structures and mechanisms that converge on the essential cellular function of IFT140 in primary cilia.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase, elevating cAMP levels, which in turn can activate PKA. This influences IFT140 indirectly through the modulation of ciliary assembly and signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Phosphodiesterase inhibitor that raises cAMP levels, synergistically enhancing PKA activity and indirectly influencing IFT140. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates SIRT1, which can have a role in ciliogenesis. This may lead to an indirect upregulation of IFT140 to maintain ciliary structure. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Activates RAR/RXR nuclear receptors, thereby influencing ciliogenesis, possibly increasing the demand for IFT140. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
Activates G-protein coupled receptors to increase intracellular calcium levels, indirectly affecting IFT140 by promoting ciliogenesis. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
JNK pathway activator, potentially influencing IFT140 by upregulating ciliary assembly. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium, influencing the calmodulin pathway and thereby possibly augmenting IFT140 function in ciliogenesis. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates PKC, thereby affecting ciliary function. This may indirectly require increased IFT140 for proper cilia maintenance. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Glucocorticoid receptor activator, influences ciliogenesis and could thereby affect IFT140 indirectly. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Phosphodiesterase-4 inhibitor, elevates cAMP, indirectly affecting IFT140 via PKA activation and ciliary assembly. | ||||||