Id4 Activators
Id4, or Inhibitor of DNA binding 4, is a member of the Id (Inhibitor of differentiation) family of helix-loop-helix (HLH) transcription factors. Unlike typical HLH proteins that form heterodimers with other bHLH transcription factors to regulate gene expression, Id proteins lack a DNA-binding domain and act as dominant-negative regulators by sequestering bHLH proteins and preventing them from binding to DNA. Id4 is implicated in various cellular processes including cell proliferation, differentiation, and apoptosis, and it plays crucial roles in embryonic development, tissue homeostasis, and tumorigenesis.
The activation of Id4 is regulated by multiple mechanisms at transcriptional, post-transcriptional, and post-translational levels. Transcriptionally, Id4 expression can be induced by various signaling pathways such as the Wnt, TGF-β, and BMP pathways, which converge on specific response elements within the Id4 promoter region. Additionally, epigenetic modifications, including DNA methylation and histone acetylation, can modulate Id4 expression levels by regulating chromatin accessibility. At the post-transcriptional level, microRNAs and RNA-binding proteins can fine-tune Id4 expression by modulating mRNA stability and translation efficiency. Furthermore, post-translational modifications such as phosphorylation, ubiquitination, and SUMOylation can influence Id4 protein stability, subcellular localization, and interaction with binding partners, thereby impacting its transcriptional activity and biological functions. Understanding the intricate regulatory mechanisms governing Id4 activation is essential for elucidating its roles in normal development and disease pathogenesis.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $100.00 $380.00 | 15 | |
SB-3CT is a matrix metalloproteinase (MMP) inhibitor that indirectly influences Id4. By inhibiting MMPs, SB-3CT disrupts the extracellular matrix and cell signaling. This disruption can affect the balance of signaling pathways involved in cellular differentiation, potentially impacting Id4 expression and function. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 is a small molecule inhibitor of Wnt production. Wnt signaling is known to play a role in cell fate determination, and its inhibition by IWP-2 can indirectly affect Id4 through modulation of downstream pathways. The disruption of Wnt signaling may influence cellular differentiation processes, potentially impacting Id4 expression and activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), which is involved in cytoskeletal dynamics. By inhibiting ROCK, Y27632 can influence cellular morphology and signaling pathways related to differentiation. The indirect impact of Y27632 on cellular processes may lead to alterations in Id4 expression and function. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $75.00 $150.00 $215.00 $650.00 $1224.00 $4296.00 $7818.00 | 8 | |
ALK5 Inhibitor II (RepSox) is a selective inhibitor of the TGF-β type I receptor, disrupting TGF-β signaling. As TGF-β plays a role in cell fate decisions, the inhibition by RepSox can indirectly affect pathways related to cellular differentiation, potentially impacting Id4 expression and function. The modulation of TGF-β signaling by RepSox provides a mechanism for the indirect regulation of Id4 in the context of cellular differentiation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of c-Jun N-terminal kinase (JNK), a member of the MAPK family. By inhibiting JNK, SP600125 can affect cellular responses related to stress and differentiation. The indirect modulation of JNK signaling may influence Id4 expression and function in the context of cellular differentiation processes. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT is a γ-secretase inhibitor that affects Notch signaling. Notch signaling is involved in cell fate decisions, and the inhibition by DAPT can indirectly impact Id4 expression and cellular processes related to differentiation. The modulation of Notch signaling by DAPT provides a mechanism for the indirect regulation of Id4 in the context of cellular differentiation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a selective inhibitor of the TGF-β type I receptor, blocking TGF-β signaling. The inhibition of TGF-β signaling by SB431542 can indirectly affect pathways related to cellular differentiation, potentially influencing Id4 expression and function. The modulation of TGF-β signaling by SB431542 provides a mechanism for the indirect regulation of Id4 in the context of cellular differentiation processes. | ||||||
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
JIB-04 is a Jumonji histone demethylase inhibitor, influencing epigenetic regulation. By inhibiting histone demethylases, JIB-04 can impact chromatin structure and gene expression patterns, including those related to Id4. The epigenetic modulation by JIB-04 provides a mechanism for the indirect regulation of Id4 expression and function in the context of cellular differentiation. | ||||||
GSK 690693 | 937174-76-0 | sc-363280 sc-363280A | 10 mg 50 mg | $255.00 $1071.00 | 4 | |
GSK690693 is a selective inhibitor of Akt, a key player in the PI3K/Akt signaling pathway. The inhibition of Akt by GSK690693 can influence downstream signaling cascades, potentially impacting Id4 expression and cellular processes related to differentiation and development. The modulation of Akt signaling by GSK690693 provides a mechanism for the indirect regulation of Id4 in the context of cellular differentiation processes. | ||||||
JNK Inhibitor VIII | 894804-07-0 | sc-202673 | 5 mg | $267.00 | 2 | |
JNK Inhibitor VIII is a selective inhibitor of c-Jun N-terminal kinase (JNK), a member of the MAPK family. By inhibiting JNK, this compound can influence cellular responses related to stress and differentiation. The indirect modulation of JNK signaling may impact Id4 expression and function in the context of cellular differentiation processes. | ||||||