Date published: 2025-10-23

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IκB-β Inhibitors

IκB-β inhibitors belong to a class of chemical compounds that primarily target the IκB-β protein, a crucial regulator in the nuclear factor-kappa B (NF-κB) signaling pathway. The NF-κB pathway plays a pivotal role in orchestrating various cellular responses, including immune and inflammatory reactions, cell proliferation, and apoptosis. IκB-β, a member of the IκB family of proteins, serves as a cytoplasmic inhibitor of NF-κB by sequestering it in an inactive form. When certain external stimuli, such as pro-inflammatory cytokines or pathogens, activate the NF-κB pathway, IκB-β is phosphorylated and subsequently degraded, allowing NF-κB to translocate into the nucleus and activate the transcription of various genes involved in inflammation and immune responses.

IκB-β inhibitors, as the name suggests, are compounds designed to interfere with the degradation of IκB-β or prevent its phosphorylation, thereby modulating the NF-κB pathway. These inhibitors may act through various mechanisms, including competitive binding to specific sites on IκB-β or its upstream kinases. By inhibiting the degradation or phosphorylation of IκB-β, these compounds can attenuate the activation of NF-κB, leading to a reduced expression of NF-κB-dependent genes. This can be particularly relevant in contexts where excessive NF-κB activity contributes to chronic inflammatory conditions or diseases. The development and study of IκB-β inhibitors have provided valuable insights into the molecular mechanisms underlying NF-κB signaling and have potential implications for research in immunology, inflammation, and cellular biology.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BAY 11-7082

19542-67-7sc-200615B
sc-200615
sc-200615A
5 mg
10 mg
50 mg
$61.00
$83.00
$349.00
155
(1)

Inhibits IκB kinase (IKK) and prevents IκB-β degradation.

SC514

354812-17-2sc-205504
sc-205504A
5 mg
10 mg
$66.00
$89.00
13
(2)

Blocks IKK2 activity and stabilizes IκB-β, inhibiting NF-κB.

Wedelolactone

524-12-9sc-200648
sc-200648A
1 mg
5 mg
$108.00
$330.00
8
(0)

Alters the phosphorylation of IκB-β, preventing its degradation.

IMD 0354

978-62-1sc-203084
5 mg
$199.00
3
(1)

Selectively inhibits IKKβ, preventing IκB-β phosphorylation.

IKK Inhibitor X

431898-65-6sc-221742
5 mg
$345.00
3
(0)

Inhibits IKK2 and prevents the phosphorylation of IκB-β.

BMS-345541

445430-58-0sc-221741
1 mg
$306.00
1
(1)

Selective IKK inhibitor that affects IκB-β degradation.

ML 120B Dihydrochloride

783348-36-7 (free base)sc-487759
5 mg
$380.00
(0)

Targets IKKβ and reduces IκB-β phosphorylation.

IKK-2 Inhibitor IV

507475-17-4sc-203083
500 µg
$130.00
12
(1)

Blocks IKK2, preventing IκB-β phosphorylation and degradation.

THZ1

1604810-83-4sc-507542
1 mg
$95.00
(0)

Affects CDK7/12, indirectly modulating IκB-β expression.