IκB-β inhibitors belong to a class of chemical compounds that primarily target the IκB-β protein, a crucial regulator in the nuclear factor-kappa B (NF-κB) signaling pathway. The NF-κB pathway plays a pivotal role in orchestrating various cellular responses, including immune and inflammatory reactions, cell proliferation, and apoptosis. IκB-β, a member of the IκB family of proteins, serves as a cytoplasmic inhibitor of NF-κB by sequestering it in an inactive form. When certain external stimuli, such as pro-inflammatory cytokines or pathogens, activate the NF-κB pathway, IκB-β is phosphorylated and subsequently degraded, allowing NF-κB to translocate into the nucleus and activate the transcription of various genes involved in inflammation and immune responses.
IκB-β inhibitors, as the name suggests, are compounds designed to interfere with the degradation of IκB-β or prevent its phosphorylation, thereby modulating the NF-κB pathway. These inhibitors may act through various mechanisms, including competitive binding to specific sites on IκB-β or its upstream kinases. By inhibiting the degradation or phosphorylation of IκB-β, these compounds can attenuate the activation of NF-κB, leading to a reduced expression of NF-κB-dependent genes. This can be particularly relevant in contexts where excessive NF-κB activity contributes to chronic inflammatory conditions or diseases. The development and study of IκB-β inhibitors have provided valuable insights into the molecular mechanisms underlying NF-κB signaling and have potential implications for research in immunology, inflammation, and cellular biology.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Inhibits IκB kinase (IKK) and prevents IκB-β degradation. | ||||||
SC514 | 354812-17-2 | sc-205504 sc-205504A | 5 mg 10 mg | $66.00 $89.00 | 13 | |
Blocks IKK2 activity and stabilizes IκB-β, inhibiting NF-κB. | ||||||
Wedelolactone | 524-12-9 | sc-200648 sc-200648A | 1 mg 5 mg | $108.00 $330.00 | 8 | |
Alters the phosphorylation of IκB-β, preventing its degradation. | ||||||
IMD 0354 | 978-62-1 | sc-203084 | 5 mg | $199.00 | 3 | |
Selectively inhibits IKKβ, preventing IκB-β phosphorylation. | ||||||
IKK Inhibitor X | 431898-65-6 | sc-221742 | 5 mg | $345.00 | 3 | |
Inhibits IKK2 and prevents the phosphorylation of IκB-β. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $306.00 | 1 | |
Selective IKK inhibitor that affects IκB-β degradation. | ||||||
ML 120B Dihydrochloride | 783348-36-7 (free base) | sc-487759 | 5 mg | $380.00 | ||
Targets IKKβ and reduces IκB-β phosphorylation. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $130.00 | 12 | |
Blocks IKK2, preventing IκB-β phosphorylation and degradation. | ||||||
THZ1 | 1604810-83-4 | sc-507542 | 1 mg | $95.00 | ||
Affects CDK7/12, indirectly modulating IκB-β expression. |