HtrA4 Activators
HtrA4 Activators encompass a range of compounds that exert their effects through modulation of cellular signaling pathways, thereby indirectly influencing the activity of the serine protease HtrA4. These activators, which include adenylate cyclase activators, kinase inhibitors, phosphatase inhibitors, and ionophores, do not directly interact with HtrA4 but create cellular conditions that are conducive to its activation. For example, compounds like Forskolin and Ionomycin increase the levels of secondary messengers cAMP and Ca2+, respectively, which can trigger downstream signaling events leading to the phosphorylation of proteins. Such phosphorylation events can modify the interaction landscape of HtrA4, potentially enhancing its protease activity.
Inhibitors like U0126, SB203580, LY294002, PD98059, and SP600125 function by disrupting specific kinase pathways, which could result in the upregulation of stress response mechanisms or alterations in cellular homeostasis, both of which could lead to an enhanced need for HtrA4 activity. Additionally, the proteasome inhibitor MG132 can lead to an accumulation of misfolded or damaged proteins, which may subsequently require increased HtrA4 activity to maintain cellular proteostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels. Elevated cAMP can activate protein kinase A (PKA), which can phosphorylate substrates that may interact with HtrA4, potentially enhancing its proteolytic activity by altering its conformation or localization. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to modulate various signaling pathways and may enhance HtrA4 activity by altering the oxidative environment, which can affect protein folding and potentially increase the availability of substrates for HtrA4. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
As a phosphatase inhibitor, sodium orthovanadate can prevent the dephosphorylation of proteins involved in signaling pathways that may regulate HtrA4 activity, thereby maintaining an active state that could enhance HtrA4 functionality. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which may phosphorylate proteins that interact with or regulate HtrA4, enhancing its protease activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially activating calcium-dependent proteases or signaling pathways that can modulate HtrA4 activity indirectly. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
This p38 MAPK inhibitor can modulate the cellular stress response, which could lead to an upregulation of protease activity, including HtrA4, as part of the cellular adaptation to stress. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
As a PI3K inhibitor, LY294002 can affect the AKT signaling pathway, which may indirectly enhance HtrA4 activity by altering the cellular environment or the phosphorylation state of proteins that interact with HtrA4. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
By inhibiting MEK and thus affecting the MAPK/ERK pathway, PD98059 can alter the cell signaling environment, potentially leading to enhanced HtrA4 activity through changes in protein interactions or localization. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
This JNK inhibitor can modify the cellular response to stress, potentially resulting in the upregulation of proteases including HtrA4, as the cell adapts to the altered signaling. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A tyrosine kinase inhibitor, Genistein can modulate various signaling pathways that might interact with HtrA4, potentially enhancing its activity through changes in the phosphorylation patterns of proteins that associate with or regulate HtrA4. | ||||||