HoxC9 Inhibitors are a specialized class of chemical compounds that target the HoxC9 transcription factor, a member of the homeobox (Hox) gene family known for its critical role in embryonic development and cellular differentiation. HoxC9 is instrumental in regulating genes involved in the establishment of the anterior-posterior axis during development, influencing the identity and function of cells in various tissues. By modulating the activity of HoxC9, these inhibitors can alter the expression patterns of downstream genes, thereby affecting fundamental biological processes such as morphogenesis, cell proliferation, and apoptosis.
Chemically, HoxC9 Inhibitors are designed to interfere with the DNA-binding capability of the HoxC9 protein or disrupt its interactions with co-factors essential for transcriptional regulation. This can be achieved through small molecules that bind directly to the homeodomain of HoxC9, preventing it from attaching to specific DNA sequences. Alternatively, some inhibitors may induce conformational changes in the protein structure, hindering its ability to form functional transcriptional complexes. These compounds often feature molecular structures that allow high specificity and affinity for HoxC9, minimizing off-target effects on other Hox proteins or transcription factors. Research into HoxC9 Inhibitors contributes to a deeper understanding of gene regulatory networks and the molecular mechanisms that control development and cellular identity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another histone deacetylase inhibitor, could influence gene expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Binds to DNA and inhibits transcription, potentially affecting HoxC9 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Intercalates into DNA, inhibiting transcription and potentially HoxC9 expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Can modulate gene expression by inhibiting tyrosine kinases. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $103.00 $429.00 $821.00 $1538.00 | 4 | |
Intercalates into DNA, inhibiting transcription and potentially HoxC9 expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Inhibits topoisomerase II, potentially affecting DNA transcription and the expression of HoxC9. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Intercalates into DNA, affecting transcription and potentially HoxC9 expression. | ||||||
Temozolomide | 85622-93-1 | sc-203292 sc-203292A | 25 mg 100 mg | $89.00 $250.00 | 32 | |
Can methylate DNA, potentially affecting the transcription of HoxC9. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Another DNA methyltransferase inhibitor, could influence gene expression including potentially that of HoxC9. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
A potent histone deacetylase inhibitor, could potentially influence the expression of HoxC9. | ||||||