HoxC11 inhibitors represent a class of chemical compounds designed to modulate the activity of the HoxC11 gene. The HoxC11 gene is a member of the Hox family, which plays a crucial role in embryonic development and cellular differentiation. The Hox genes are transcription factors that regulate the spatial patterning of cells along the anterior-posterior axis during embryogenesis. Specifically, HoxC11 is involved in the development and differentiation of various tissues, including the spinal cord and kidneys. In normal physiological conditions, the expression of HoxC11 is tightly regulated to ensure proper development and function of these tissues.
The inhibitors within this chemical class are meticulously designed to selectively target and modulate the activity of HoxC11. By interfering with the normal functioning of HoxC11, these inhibitors have the potential to influence cellular processes associated with tissue development. Researchers are exploring the molecular mechanisms through which HoxC11 inhibitors exert their effects, aiming to gain insights into the intricate regulatory networks that govern embryonic development. Understanding the specific interactions between these inhibitors and the HoxC11 gene may open new avenues for manipulating gene expression patterns, providing valuable tools for investigating fundamental biological processes related to tissue development and differentiation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
A steroidal alkaloid that inhibits the Hedgehog signaling pathway, which may interact with Hox genes during embryonic development. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
An inhibitor of aldehyde dehydrogenase that can affect retinoic acid signaling, potentially influencing Hox gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, which could lead to demethylation and altered expression of Hox genes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
A histone deacetylase inhibitor, potentially affecting the acetylation state of histones near Hox genes and altering their expression. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
An inhibitor of the BET family of bromodomain proteins, potentially impacting the expression of genes regulated by HoxC11. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
An inhibitor of the Wnt signaling pathway, which may cross-talk with Hox gene-regulated developmental processes. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
A FGFR inhibitor, which could affect fibroblast growth factor signaling pathways that interact with Hox gene expression. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
A GSK-3 inhibitor, which may modulate the Wnt pathway and consequently affect Hox gene-regulated processes. | ||||||