Date published: 2025-10-16

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Homobifunctional Crosslinkers

Santa Cruz Biotechnology now offers a broad range of homobifunctional crosslinkers for use in various applications. Homobifunctional crosslinkers are chemical reagents that possess two identical reactive groups, enabling them to covalently link two similar functional groups within or between molecules. These crosslinkers are crucial in scientific research for studying protein-protein interactions, stabilizing protein structures, and creating multi-subunit complexes. Researchers utilize homobifunctional crosslinkers to investigate the spatial organization and dynamics of macromolecular assemblies, providing insights into the structural and functional relationships within biological systems. These crosslinkers are also employed in the development of biomaterials, where they enhance the mechanical properties and stability of synthetic polymers and hydrogels. In addition, homobifunctional crosslinkers play a significant role in immobilizing enzymes and other bioactive molecules onto solid supports, facilitating their use in biosensors, bioassays, and biocatalysis. By offering a comprehensive selection of high-quality homobifunctional crosslinkers, Santa Cruz Biotechnology supports advanced research in biochemistry, molecular biology, and materials science. These products enable scientists to achieve precise and reproducible results, driving innovations in the understanding of molecular interactions and the development of new biotechnological applications. View detailed information on our available homobifunctional crosslinkers by clicking on the product name.

Items 41 to 50 of 60 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Bis[2-(4-azidosalicylamido)ethyl] disulfide

199804-21-2sc-239377
10 mg
$265.00
(0)

Bis[2-(4-azidosalicylamido)ethyl] disulfide is a homobifunctional compound featuring azide groups that enable efficient click chemistry reactions, particularly with alkynes. Its disulfide linkage provides a reversible bond, allowing for dynamic covalent interactions. The presence of salicylamide moieties enhances hydrogen bonding capabilities, promoting specific molecular recognition. This compound's unique reactivity and structural features facilitate the formation of tailored polymeric networks and complex molecular architectures.

Bis-(2-methanethiosulfonatoethyl)dimethylammonium Chloride

sc-217766
5 mg
$360.00
(0)

Bis-(2-methanethiosulfonatoethyl)dimethylammonium Chloride is a homobifunctional compound characterized by its dual methanethiosulfonate groups, which facilitate thiol-mediated reactions. Its dimethylammonium moiety enhances solubility and ionic interactions, promoting effective cross-linking in various environments. The compound exhibits unique reactivity through its ability to form stable thioether bonds, enabling the construction of complex molecular frameworks and enhancing material properties through tailored interactions.

Decaoxadotriacontadioic Acid Bis(N-Hydroxysuccinimide) Ester

sc-218093
5 mg
$430.00
(0)

Decaoxadotriacontadioic Acid Bis(N-Hydroxysuccinimide) Ester is a homobifunctional compound distinguished by its dual N-hydroxysuccinimide ester groups, which enable efficient amine coupling reactions. This structure promotes selective conjugation, enhancing the formation of stable linkages. Its unique reactivity profile allows for controlled polymerization and cross-linking, facilitating the development of intricate molecular architectures and tailored material properties through specific interaction pathways.

Nonaoxanonacosanedioic Acid Bis(N-Hydroxysuccinimide) Ester

sc-219394
5 mg
$430.00
(0)

Nonaoxanonacosanedioic Acid Bis(N-Hydroxysuccinimide) Ester is a homobifunctional molecule characterized by its two N-hydroxysuccinimide ester moieties, which facilitate targeted amine reactions. This compound exhibits a high degree of specificity in conjugation, allowing for the formation of robust covalent bonds. Its unique structural features promote versatile reaction kinetics, enabling the design of complex networks and enhancing the stability of resultant materials through precise molecular interactions.

Octaoxahexacosanedioic Acid Bis(N-Hydroxysuccinimide) Ester

sc-219459
5 mg
$430.00
(0)

Octaoxahexacosanedioic Acid Bis(N-Hydroxysuccinimide) Ester is a homobifunctional compound distinguished by its dual N-hydroxysuccinimide ester groups, which enable selective coupling with amine functionalities. This molecule showcases remarkable reactivity, allowing for efficient cross-linking and the formation of intricate polymeric structures. Its extended carbon chain enhances solubility and flexibility, promoting diverse molecular interactions that can lead to tailored material properties and improved stability in various environments.

1,5-Pentanediyl Bismethanethiosulfonate

56-00-8sc-208802
25 mg
$360.00
(0)

1,5-Pentanediyl Bismethanethiosulfonate is a homobifunctional compound characterized by its unique thiol-reactive groups, which facilitate the formation of disulfide bonds. This molecule exhibits rapid reaction kinetics, enabling efficient cross-linking in various chemical environments. Its structural design promotes specific molecular interactions, enhancing the stability and integrity of resulting networks. The compound's distinct pathways for thiol modification contribute to versatile applications in material science and bioconjugation.

1,8-Octadiyl Bismethanethiosulfonate

4356-71-2sc-208815
25 mg
$330.00
(0)

1,8-Octadiyl Bismethanethiosulfonate is a homobifunctional compound featuring two reactive thiol groups that enable selective cross-linking and polymerization. Its elongated hydrocarbon chain enhances solubility and flexibility, allowing for unique molecular interactions in diverse environments. The compound exhibits notable reactivity under mild conditions, facilitating efficient conjugation processes. Its structural attributes promote tailored modifications, making it suitable for innovative applications in materials development and surface chemistry.

1,6-Bis-maleimidohexane

4856-87-5sc-357486
100 mg
$274.00
(0)

1,6-Bis-maleimidohexane is a homobifunctional compound characterized by its two maleimide groups, which facilitate efficient thiol-ene click reactions. This compound exhibits a unique ability to form stable covalent bonds with thiol-containing molecules, promoting robust cross-linking in polymer networks. Its symmetrical structure enhances reaction kinetics, allowing for rapid conjugation under mild conditions. The compound's flexibility and reactivity make it a versatile tool for creating complex molecular architectures.

Bis-maleimidomethyl Ether

15209-14-0sc-210928
25 mg
$380.00
(0)

Bis-maleimidomethyl Ether is a homobifunctional compound featuring two maleimide functionalities that enable selective and efficient reactions with thiol groups. Its unique structure allows for the formation of stable covalent linkages, promoting the development of intricate polymer networks. The compound's reactivity is enhanced by its ability to undergo rapid Michael additions, facilitating dynamic cross-linking and enabling the creation of diverse materials with tailored properties.

Sebacic acid bis(N-succinimidyl) ester

23024-29-5sc-253546
100 mg
$63.00
(0)

Sebacic acid bis(N-succinimidyl) ester is a homobifunctional reagent characterized by its two N-succinimidyl ester groups, which facilitate efficient coupling reactions with amine-containing molecules. This compound exhibits a high degree of specificity in forming stable amide bonds, promoting the creation of complex biomolecular architectures. Its reactivity is influenced by the stability of the succinimidyl leaving group, allowing for controlled reaction kinetics and the formation of diverse conjugates in various chemical environments.