Date published: 2025-10-17

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1,5-Pentanediyl Bismethanethiosulfonate (CAS 56-00-8)

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CAS Number:
56-00-8
Molecular Weight:
292.46
Molecular Formula:
C7H16O4S4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,5-Pentanediyl Bismethanethiosulfonate is a sulfhydryl cross-linking reagent.


1,5-Pentanediyl Bismethanethiosulfonate (CAS 56-00-8) References

  1. Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers.  |  Loo, TW. and Clarke, DM. 2001. J Biol Chem. 276: 36877-80. PMID: 11518701
  2. Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site.  |  Loo, TW. and Clarke, DM. 2002. Proc Natl Acad Sci U S A. 99: 3511-6. PMID: 11891276
  3. The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator.  |  Chen, EY., et al. 2004. J Biol Chem. 279: 39620-7. PMID: 15272010
  4. Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.  |  Loo, TW., et al. 2006. Biochem J. 399: 351-9. PMID: 16813563
  5. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein.  |  Wang, Y., et al. 2007. J Biol Chem. 282: 33247-33251. PMID: 17911111
  6. Probing the structure of the dimeric KtrB membrane protein.  |  Albright, RA., et al. 2007. J Biol Chem. 282: 35046-55. PMID: 17932047
  7. Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporter.  |  Pagant, S., et al. 2008. J Biol Chem. 283: 26444-51. PMID: 18644782
  8. Intragenic suppressing mutations correct the folding and intracellular traffic of misfolded mutants of Yor1p, a eukaryotic drug transporter.  |  Pagant, S., et al. 2010. J Biol Chem. 285: 36304-14. PMID: 20837481
  9. Asymmetry in the homodimeric ABC transporter MsbA recognized by a DARPin.  |  Mittal, A., et al. 2012. J Biol Chem. 287: 20395-406. PMID: 22523072
  10. Structural Studies of Multidrug Resistance Protein 1 Using 'Almost' Cysless Template.  |  Trofimova, DN. and Deeley, RG. 2018. Drug Metab Dispos. 46: 794-804. PMID: 29572332

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,5-Pentanediyl Bismethanethiosulfonate, 25 mg

sc-208802
25 mg
$360.00