hnRNP L Inhibitors
The class of hnRNP L inhibitors comprises a diverse set of chemical compounds designed to modulate the activity of heterogeneous nuclear ribonucleoprotein L. These inhibitors act through various mechanisms, directly or indirectly influencing the splicing machinery and hnRNP L's regulatory functions in RNA processing and gene expression. Compounds such as Meayamycin, Pladienolide B, Spliceostatin A, E7107, and H3B-8800 directly inhibit hnRNP L by targeting the SF3B1 subunit of the spliceosome. By disrupting spliceosome assembly and altering pre-mRNA splicing events, these inhibitors impact hnRNP L's function in cellular processes.
Additionally, THZ1 indirectly inhibits hnRNP L by targeting CDK7, affecting RNA polymerase II-mediated transcription and the synthesis of hnRNP L. This indirect inhibition offers a unique perspective on modulating hnRNP L activity through transcriptional regulation. Furthermore, inhibitors like Herboxidiene, E7107 analog, FR901464, Sudemycin D6, Pladienolide D, and SSA/RN-1 target the SF3B1 subunit of the spliceosome, disrupting spliceosome assembly and altering pre-mRNA splicing events. These compounds provide valuable tools for studying hnRNP L modulation and its consequences on cellular processes. The diverse array of hnRNP L inhibitors presented here offers researchers an extensive toolkit for investigating the intricate regulatory roles of hnRNP L in RNA metabolism and gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B is a chemical compound that inhibits hnRNP L by targeting the SF3B1 subunit of the spliceosome. By binding to SF3B1, Pladienolide B disrupts spliceosome assembly and influences alternative splicing events. This interference with the splicing process results in the inhibition of hnRNP L, impacting its role in RNA metabolism and gene expression regulation. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Spliceostatin A is a chemical compound known to inhibit hnRNP L by targeting the SF3B1 subunit of the spliceosome. It disrupts spliceosome assembly and alters pre-mRNA splicing events, leading to the inhibition of hnRNP L function in RNA processing and gene expression regulation. The compound's interference with the splicing machinery highlights its potential as a modulator of hnRNP L activity. | ||||||
THZ1 | 1604810-83-4 | sc-507542 | 1 mg | $95.00 | ||
THZ1 is a chemical compound that indirectly inhibits hnRNP L by targeting CDK7, a cyclin-dependent kinase. THZ1's action on CDK7 results in the inhibition of RNA polymerase II-mediated transcription, affecting the synthesis of hnRNP L and other RNA-binding proteins. This indirect inhibition impacts hnRNP L's availability and function in cellular processes, providing a unique perspective on modulating its activity through transcriptional regulation. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Herboxidiene is a chemical compound known to inhibit hnRNP L by interfering with the SF3B1 subunit of the spliceosome. Its action disrupts spliceosome assembly and alters pre-mRNA splicing events, leading to the inhibition of hnRNP L function in RNA processing and gene expression regulation. Herboxidiene's impact on the splicing machinery makes it a valuable tool for studying hnRNP L modulation and its consequences on cellular processes. | ||||||
FR901464 | 146478-72-0 | sc-507352 | 5 mg | $1800.00 | ||
FR901464 is a chemical compound that inhibits hnRNP L by targeting the SF3B1 subunit of the spliceosome. Its interference with spliceosome assembly disrupts pre-mRNA splicing events, leading to the inhibition of hnRNP L function in RNA processing and gene expression regulation. FR901464's impact on the splicing machinery positions it as a valuable tool for studying hnRNP L modulation and its consequences on cellular processes. | ||||||