Date published: 2026-4-5

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HMGCR Antibodies

Santa Cruz Biotechnology delivers a wide array of HMGCR monoclonal antibodies for research in cholesterol metabolism and related pathways. HMGCR monoclonal antibodies are compatible with multiple techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) plays a crucial role in the mevalonate pathway, which is essential for the biosynthesis of cholesterol and other isoprenoids. As a key regulatory enzyme, HMGCR is a target for statin drugs, which are widely used to manage cholesterol levels and reduce cardiovascular risk. Understanding the function and regulation of HMGCR is vital for advancing therapeutic strategies in lipid disorders and metabolic diseases. HMGCR research has significant implications for cardiovascular health and metabolic regulation. Investigating HMGCR activity patterns helps reveal new insights into cholesterol synthesis pathways. Current research focuses on understanding how HMGCR regulation affects various metabolic conditions. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing our understanding of cholesterol metabolism and its impact on human health.

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HMGCR Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

HMGCR Antibody (C-1)

sc-271595mouse IgG1 κ589-888 (h)WB, IP, IF, IHC(P), ELISAm, r, h
65
(21)

HMGCR CRISPR Knockout, HDR and Double Nickase Plasmids

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HMGCR CRISPR/Cas9 KO Plasmid (h)

sc-400560hGene KnockoutGFP0
(0)

HMGCR HDR Plasmid (h)

sc-400560-HDRhHomology Directed RepairPuromycin0
(0)

HMGCR Double Nickase Plasmid (h)

sc-400560-NIChGene KnockoutPuromycin0
(0)

HMGCR Double Nickase Plasmid (h2)

sc-400560-NIC-2hGene KnockoutPuromycin0
(0)

HMGCR CRISPR/Cas9 KO Plasmid (m)

sc-420877mGene KnockoutGFP0
(0)

HMGCR HDR Plasmid (m)

sc-420877-HDRmHomology Directed RepairPuromycin0
(0)

HMGCR CRISPR Activation Products

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HMGCR CRISPR Activation Plasmid (h)

sc-400560-ACThGene ActivationPuro, Blast, Hygro0
(0)

HMGCR CRISPR Activation Plasmid (h2)

sc-400560-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HMGCR CRISPR Activation Plasmid (m)

sc-420877-ACTmGene ActivationPuro, Blast, Hygro0
(0)

HMGCR siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

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HMGCR siRNA (h)

sc-43838hGene SilencingN/A
3
(0)

HMGCR shRNA Plasmid (h)

sc-43838-SHhGene SilencingPuromycin
3
(0)

HMGCR shRNA (h) Lentiviral Particles

sc-43838-VhGene SilencingPuromycin
3
(0)

HMGCR siRNA (m)

sc-44851mGene SilencingN/A
1
(0)

HMGCR shRNA Plasmid (m)

sc-44851-SHmGene SilencingPuromycin
1
(0)

HMGCR shRNA (m) Lentiviral Particles

sc-44851-VmGene SilencingPuromycin
1
(0)

HMGCR Transfected Lysates

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HMGCR (m2): 293T Lysate

sc-120842m20
(0)