HIV-1 Tat-SF1 Inhibitors

The inhibitors listed above primarily target transcriptional regulation and HIV replication processes, which could indirectly influence HIV-1 Tat-SF1 activity. Given Tat-SF1's role in HIV transcription and replication, modulation of these processes is relevant for understanding its function and potential regulation. Flavopiridol and DRB, by inhibiting CDK9 and CDK7, can affect transcription elongation, potentially impacting Tat-SF1's function. Triptolide, targeting the Pol II complex, and BET bromodomain inhibitors (JQ1 and I-BET151) can modulate transcription, potentially influencing Tat-SF1 activity.

Curcumin and compounds like Prostratin and SAHA, which modulate HIV transcription and latency, could indirectly affect Tat-SF1's role in HIV replication. Disulfiram, by affecting latent HIV, and epigenetic modulators like Chaetocin and RG-108, can impact transcriptional regulation, potentially influencing Tat-SF1. Pladienolide B, targeting spliceosome, might indirectly affect processes relevant to Tat-SF1 in HIV replication.