Histone H2BM Activators

Histone deacetylase inhibitors like Trichostatin A, Sodium butyrate, and SAHA (Vorinostat) enhance histone acetylation levels, affecting Histone H2BM and its role in chromatin remodeling. Increased acetylation generally leads to a more open chromatin structure, facilitating gene transcription. In contrast, inhibitors of histone methyltransferases (like Methylstat and BIX-01294) and DNA methyltransferases (such as 5-Azacytidine and RG108) can alter the methylation landscape, indirectly impacting Histone H2BM and gene expression regulation.

Compounds like Curcumin, which influences multiple cellular pathways, and JQ1, targeting BET bromodomains, represent broader approaches to modulating chromatin dynamics and affecting Histone H2BM. Inhibitors of histone acetyltransferases, including Anacardic Acid, Disulfiram, and C646, also contribute to the regulation of histone acetylation, indirectly influencing the function and role of Histone H2BM in chromatin structure.