Histone cluster 3 H2ba Inhibitors
Histone cluster 3 H2BA inhibitors comprise a specialized class of chemical compounds designed to modulate the activity of histone cluster 3 H2BA proteins. H2BA, also known as H2B histone family member A, is a crucial component of the histone family of proteins found in humans and various organisms. Histones are essential for chromatin structure and gene regulation. Chromatin, the complex structure formed by DNA and histones in the cell nucleus, is central to the organization and packaging of genetic material. H2BA, as a subtype of histone H2B, plays a significant role in maintaining the dynamic structure of chromatin, which in turn influences gene expression, DNA replication, and genome stability.
H2BA inhibitors typically consist of small molecules or chemical compounds meticulously engineered to interact with H2BA proteins, targeting either their active sites or allosteric sites. This interaction can lead to the modulation of H2BA's behavior, potentially impacting its role in chromatin structure, gene expression, and DNA packaging. Researchers in the fields of molecular biology and pharmacology are dedicated to uncovering the molecular mechanisms and functions of histone cluster 3 H2BA proteins within the context of chromatin dynamics, aiming to gain insights into the intricate processes that govern epigenetic regulation and genomic stability. The development of H2BA inhibitors represents an ongoing and dynamic area of research, contributing significantly to our understanding of chromatin biology and its critical role in gene expression and various cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
This compound inhibits RNA polymerase II, potentially downregulating mRNA synthesis and thereby affecting histone gene expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interacts with DNA and can inhibit RNA synthesis, potentially reducing expression of genes including histones. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibits RNA polymerase II-dependent transcription elongation, which could decrease expression of various genes. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits DNA topoisomerase I, leading to DNA damage and potentially reduced transcription of certain genes. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $147.00 $258.00 $508.00 $717.00 $1432.00 | 1 | |
A nucleoside analog that inhibits DNA synthesis, which could lead to the downregulation of histone expression. | ||||||
Aclacinomycin A | 57576-44-0 | sc-200160 | 5 mg | $129.00 | 10 | |
Interacts with DNA and influences transcription and replication processes, potentially affecting gene expression. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $51.00 $123.00 $178.00 | 11 | |
Inhibits protein synthesis at the level of translation elongation, which could reduce histone protein levels. | ||||||
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $330.00 $898.00 | 7 | |
Binds to DNA topoisomerase II, inhibiting its function and potentially affecting transcription and gene expression. | ||||||