Histone cluster 1 H2AA4 Inhibitors
Histone cluster 1 H2AA4 Inhibitors form a distinctive category of chemical compounds engineered to selectively inhibit the activity of histone cluster 1, with a specific focus on the H2AA4 subtype. Histones are integral proteins involved in the structuring of DNA within the cell nucleus, forming nucleosomes that serve as the fundamental building blocks of chromatin. The H2AA4 designation refers to a variant of histone H2A, a core histone essential for nucleosome assembly. As a specific subtype within histone cluster 1, H2AA4 becomes a key target for researchers seeking to unravel the intricate dynamics of chromatin and gene regulation.
The development of inhibitors specific to Histone cluster 1 H2AA4 entails a meticulous understanding of the structural characteristics of histone H2AA4 and its unique role within chromatin organization. These inhibitors are designed for precision, with the goal of selectively binding to crucial regions of Histone cluster 1 H2AA4 to disrupt its normal functions. Utilizing these inhibitors in experimental contexts enables researchers to explore the repercussions of inhibiting this particular histone variant, providing valuable insights into chromatin remodeling and the complex regulation of gene expression. The study of histones, including variants like H2AA4, contributes significantly to advancing our understanding of epigenetic mechanisms, offering critical insights into the dynamic processes governing gene regulation and the intricate orchestration of cellular functions at the chromatin level.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analog of cytidine that can be incorporated into RNA and DNA during replication and transcription, leading to demethylation and potentially inhibiting the expression of genes, including those coding for histones. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is a G9a histone methyltransferase inhibitor, which could lead to reduced methylation of histones and affect their expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can chelate copper and has been shown to inhibit the proteasome, which may affect the turnover of transcription factors that regulate histone gene expression. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Chaetocin is a specific inhibitor of the histone methyltransferase SUV39H1, potentially reducing methylation of histone H3K9 and affecting the expression of histone genes. | ||||||
N-Methyl-N-propargylbenzylamine | 555-57-7 | sc-236062 | 5 g | $68.00 | ||
Pargyline is a monoamine oxidase inhibitor that may also affect histone methylation and acetylation, thus potentially influencing histone expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a natural compound from green tea that has been shown to modulate DNA methylation and histone acetylation, potentially affecting histone gene expression. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid inhibits histone acetyltransferase (HAT) activity, which could lead to changes in chromatin structure and influence the expression of histone genes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to have inhibitory effects on histone acetyltransferases, which may impact histone acetylation and gene expression. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
Garcinol is an inhibitor of HATs and can alter chromatin structure and function, potentially affecting histone gene expression. | ||||||
2-Mercaptobenzothiazole | 149-30-4 | sc-238106 sc-238106A | 10 g 50 g | $21.00 $68.00 | ||
MB-3 is a compound that can chelate metals and may interfere with metal-dependent transcription factors or enzymes that regulate histone gene expression. | ||||||