Chaetocin CAS: 28097-03-2
MF: C30H28N6O6S4
MW: 696.84
A lysine-specific histone methyltransferase inhibitor.

Chaetocin (CAS 28097-03-2)

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Sinônimo Methyltransferase inhibitor
Aplicação A lysine-specific histone methyltransferase inhibitor
Numero VAT: 28097-03-2
Privada: ≥98%
Peso Molecular: 696.84
Separar por Funcao: C30H28N6O6S4
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Chaetocin, a natural product originally produced by Chaetomium species, is shown to have apoptotic effects on some cancer cells. Mechanistic studies show that chaetocin is taken up in the cells by a process that requires intact/unreduced disulfides for uptake. Once inside, this compound imposes oxidative stress and consequent apoptosis induction. Other studies have shown chaetocin to reduce lysine-specific histone methyltransferase effects of SUV39H, which play a key role in maintaining stable gene expression patterns during embryonic development and cellular differentiation. Additionally, this agent is reported to cause profound chromatin reorganization in fibroblast nuclei by inducing chromatin condensation/clustering. Consequentially, chaetocin impairs Trx (thioredoxin) systems, which are essential for deoxynucleotide synthesis and involved in a broad range of cellular functions. Chaetocin is an inhibitor of G9a, SUV39H1 and TrxR1.


Referencias

1. Greiner, Dorothea., et al., 2005. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Nature chemical biology. 1(3): 143-5. PMID: 16408017
2. Isham, Crescent R., et al., 2007. Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. Blood. 109(6): 2579-88. PMID: 17090648
3. Illner, Doris., et al., 2010. Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin. Experimental cell research. 316(10): 1662-80. PMID: 20302859

Estado físico :
Solid
Derivado de :
Chaetomium
envie :
Soluble in DMSO (~25 mg/ml), and ethanol (25 mg/ml).
Manutencao :
Store at -20° C
Densidade :
~1.9 g/cm3 (Predicted)
Indice de produtos :
n20D 1.93
IC50 :
HeLa cells: IC50 = 0.05 µg/ml; HMT SU(VAR)3-9: IC50 = 0.6 µm (Drosophila melanogaster); ortholog: IC50 = 0.8 µm (human); HMT SU(VAR)3-9 : IC50 = 0.8 µm; G9a: IC50 = 2.5 µm; DIM5: IC50 = 3 µm; Lys9-HMTs: IC50 = >90 µm
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
RTECS :
FM3032000
PubChem CID :
11657687
Numero de FAX :
MFCD00133163
SMILES :
CN1C(=O)[[email protected]@]23C[[email protected]]4([[email protected]@H](N2C(=O)[[email protected]@]1(SS3)CO)NC5=CC=CC=C54)[[email protected]]67C[[email protected]]89C(=O)N([[email protected]](C(=O)N8[[email protected]]6NC1=CC=CC=C71)(SS9)CO)C

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Chaetocin  Citacoes dos Produtos

Visualizar com outras pessoas usaram Chaetocin. Clique em PubMed para ver .

Citações 1 para 4 de 4 total

PMID: # 27141211  Rombo, R. et al. 2016. German medical science : GMS e-journal. 14: Doc04.

PMID: # 27924221  Liu, L. et al. 2016. Cell Discov. 2: 16036.

PMID: # 27467759  Das, S. et al. 2016. PLoS ONE. 11: e0160022.

PMID: # 31811153  Nat Commun. 10: 5594.

Citações 1 para 4 de 4 total
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