HGFL β Inhibitors
HGFL β inhibitors are a class of chemical compounds that specifically target hepatocyte growth factor-like protein β (HGFL β), a protein involved in cell signaling and regulation. HGFL β is structurally similar to hepatocyte growth factor (HGF) and plays a role in various cellular processes, including cell growth, motility, and differentiation. It is a ligand for receptors such as the RON (Recepteur d'Origine Nantais) tyrosine kinase receptor, which, when activated, initiates a cascade of intracellular signaling pathways. These pathways regulate various physiological functions, particularly those related to tissue remodeling and immune responses. HGFL β inhibitors work by blocking the interaction between HGFL β and its receptor, thereby disrupting the downstream signaling that these processes rely on.
The mechanism of action for HGFL β inhibitors typically involves binding to either the HGFL β protein or its receptor, preventing their interaction. This inhibition blocks the receptor's ability to phosphorylate and activate associated signaling molecules. By interfering with the HGFL β pathway, these inhibitors can modulate cellular behaviors such as migration and proliferation, as HGFL β plays a role in orchestrating the response of cells to external signals. These inhibitors are essential for studying the specific contributions of HGFL β to cell signaling networks and for exploring the broader implications of HGFL β in maintaining cellular homeostasis. Through their inhibition of this signaling axis, researchers can better understand how HGFL β contributes to various cellular and molecular processes and its role in orchestrating communication between cells in different tissue contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This compound could repress transcription of the MST1 gene encoding HGFL β by altering acetylation status of histones, which would result in a more condensed chromatin structure and a consequent decrease in the accessibility of the gene to transcription machinery. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Could lead to hypomethylation of the promoter region of the MST1 gene, potentially resulting in the transcriptional silencing of HGFL β through changes in DNA methylation patterns, typically associated with gene expression downregulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
May hinder the mTOR signaling pathway, leading to a reduction in the translation of many proteins, including the potential to downregulate the synthesis of HGFL β. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This compound could block the transcription elongation process of the MST1 gene by binding to DNA, which would lead to a decrease in the production of HGFL β mRNA and, consequently, the protein itself. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
May inhibit the elongation step of eukaryotic protein synthesis, leading to a broad reduction in protein levels, including a decrease in the level of HGFL β. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Could inhibit RNA polymerase II, severely reducing mRNA synthesis from genes including MST1, thereby leading to a pronounced decrease in HGFL β expression. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
May inhibit cyclin-dependent kinases necessary for cell cycle progression and gene transcription, potentially leading to a reduction in HGFL β synthesis by preventing the transcription of its gene, MST1. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
This compound could disrupt the recognition of acetylated lysines by BET bromodomains, possibly resulting in a targeted downregulation of transcription factors and a consequent reduction in HGFL β expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
As a specific inhibitor of MEK1/2, it could downregulate ERK signaling, leading to a decrease in the transcriptional activity of genes like MST1 and subsequent reduced production of HGFL β. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
May inhibit MEK1/2 in the MAPK/ERK pathway, potentially leading to a decrease in the transcriptional activity of MST1, culminating in lowered synthesis of HGFL β. | ||||||