HEF1 Activators
HEF1 Activators comprise a group of chemical compounds that enhance the functional activity of HEF1 through various signaling pathways, predominantly influencing cell migration, invasion, and adhesion dynamics. Forskolin, by raising intracellular cAMP levels and activating PKA, indirectly supports HEF1's role in integrin-mediated signaling, a critical pathway for cell migration. Epigallocatechin Gallate, as a kinase inhibitor, selectively reduces competitive EGFR and HER2 signaling, allowing HEF1 to more effectively participate in focal adhesion dynamics. PI3K inhibitors like LY294002 and Wortmannin indirectly bolster HEF1's function in cell motility by modulating downstream effects of the PI3K/AKT pathway, where HEF1 plays a significant role. Furthermore, U0126 and PD98059, both MEK inhibitors, indirectly enhance HEF1's involvement in cell adhesion and migration by dampening ERK pathway activity, thus shifting the cellular signaling balance in favor of pathways where HEF1 is active.
The narrative continues with compounds like Dasatinib and PP2, Src family kinase inhibitors, which indirectly augment HEF1's role in cell migration and adhesion by minimizing competing Src kinase signaling. SP600125, as a JNK pathway inhibitor, and SB203580, targeting p38 MAPK, further modulate signaling pathways to indirectly support HEF1's functions in stress fiber formation and cytoskeletal dynamics. Y-27632's inhibition of ROCK influences actin cytoskeleton reorganization, indirectly enhancing HEF1's role in cell motility. Lastly, PF-562271, a focal adhesion kinase (FAK) inhibitor, underscores HEF1's importance in integrin signaling and cell motility, as HEF1 is a crucial component in the FAK signaling pathway. Collectively, these HEF1 Activators, through their targeted effects on cellular signaling, facilitate the enhancement of HEF1-mediated functions, particularly in cell migration and adhesion processes, without necessitating direct activation or upregulation of HEF1 itself.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which in turn activates PKA. PKA phosphorylates several substrates that can enhance the functional activity of HEF1 in integrin-mediated signaling pathways, thus facilitating cell migration and invasion processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This compound acts as a kinase inhibitor, particularly affecting EGFR and HER2 pathways. By inhibiting these kinases, Epigallocatechin Gallate reduces competitive signaling pathways, thereby enhancing HEF1's role in integrin signaling and focal adhesion dynamics. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a PI3K inhibitor, LY294002 modulates PI3K/AKT pathway activity. This modulation indirectly supports HEF1's function in cell motility and invasion, as HEF1 is known to be involved in pathways downstream of PI3K. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, leading to decreased ERK pathway activity. This alteration in MAPK signaling indirectly enhances HEF1's role in the regulation of cell adhesion and migration. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is another MEK inhibitor that decreases ERK pathway activity. This reduction in MAPK signaling indirectly supports the activation and function of HEF1 in cell migration and invasion. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib, a Src family kinase inhibitor, indirectly influences HEF1 activity. By inhibiting Src kinases, Dasatinib reduces competitive signaling inputs, allowing HEF1 pathways involved in cell adhesion and migration to be more prominent. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
As a JNK inhibitor, SP600125 modulates JNK pathway activity. This modulation influences HEF1, which is involved in JNK pathway-linked cellular processes such as migration and stress fiber formation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38, it shifts the signaling equilibrium, potentially enhancing HEF1’s involvement in cytoskeletal dynamics and cell migration. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor. Inhibiting ROCK can enhance HEF1 activity by modulating actin cytoskeleton reorganization and cell motility, processes in which HEF1 is intricately involved. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. By affecting the PI3K/AKT pathway, it indirectly supports the role of HEF1 in regulating cell migration and invasion, as HEF1 functions downstream of PI3K. | ||||||