HEATR6 Inhibitors

HEATR6 inhibitors compounds that affect microtubule dynamics are prominent, including Paclitaxel, Nocodazole, Monastrol, Griseofulvin, and Colchicine. These substances target the polymerization and depolymerization of tubulin, a key component of microtubules, thereby potentially disrupting HEATR6-related activities if HEATR6 is involved in cellular transport or mitosis. Kinase inhibitors in this class, such as Alsterpaullone, Roscovitine, BI 2536, and MLN8237 (Alisertib), exert their effects by modulating the cell cycle checkpoints and mitotic spindle assembly. This modulation can impact HEATR6 if it has a role in chromosomal dynamics or cell division.

Brefeldin A, an inhibitor of vesicle trafficking between the endoplasmic reticulum and Golgi apparatus, could affect HEATR6's localization and function by altering its intracellular trafficking. Wortmannin, a phosphoinositide 3-kinase inhibitor, impacts signaling pathways that, if related to HEATR6, can modulate its cellular role. ZM447439, similar to Alisertib, targets Aurora kinases and can disrupt mitotic events such as chromosome alignment and segregation, processes in which HEATR6 might be implicated.