HEAB Inhibitors
HEAB (CLP1) inhibitors largely operate within the realm of RNA processing, particularly focusing on the nuances of mRNA splicing. These chemicals achieve this by primarily targeting the spliceosome, a dynamic assembly of proteins and RNA responsible for removing introns from pre-mRNA. Compounds such as Pladienolide B, E7107, and Spliceostatin A have shown direct binding capabilities to the spliceosome, consequently inhibiting its function and potentially interfering with the pre-mRNA processing role of CLP1.
Furthermore, chemicals like Indisulam and TG003 present an interesting angle. While Indisulam induces aberrant splicing, TG003 inhibits CLK kinases known to influence splicing events. These mechanisms can pose significant challenges to CLP1's seamless functioning in mRNA processing. Another intriguing subset includes compounds like Meayamycin and Sudemycins, which focus on specific complexes within the spliceosome, notably the SF3b complex. By affecting the dynamics of this complex, these chemicals present a potential hurdle for CLP1's involvement in the splicing pathway.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Binds to the spliceosome and inhibits splicing, which can interfere with CLP1's pre-mRNA processing role. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Binds to SF3b complex in spliceosome, potentially impacting CLP1's role. | ||||||
BIBF1120 | 656247-17-5 | sc-364433 sc-364433A | 5 mg 10 mg | $184.00 $321.00 | 2 | |
Induces aberrant splicing which can inhibit the mRNA processing involving CLP1. | ||||||
FR901464 | 146478-72-0 | sc-507352 | 5 mg | $1800.00 | ||
Affects spliceosome activity and thus can alter CLP1-mediated mRNA processing. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Inhibits spliceosome, potentially modifying CLP1's pre-mRNA processing actions. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $57.00 | 6 | |
Although primarily an ion channel blocker, it has shown effects on mRNA splicing, impacting CLP1. | ||||||
Cdc2-Like Kinase Inhibitor, TG003 | 300801-52-9 | sc-202528 sc-202528A | 5 mg 25 mg | $139.00 $548.00 | 6 | |
Inhibits CLK kinases which can influence splicing and thus potentially inhibit CLP1's function. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
Acts as a splicing inhibitor, potentially altering the mRNA processing pathway involving CLP1. | ||||||