Date published: 2025-10-11

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HDAC11 Inhibitors

Histone deacetylase 11 (HDAC11) belongs to the HDAC family, which plays a significant role in the regulation of gene expression through the removal of acetyl groups from lysine residues on histone proteins. This action leads to the condensation of chromatin and subsequent repression of gene transcription. HDAC11 is unique within the HDAC family due to its distinct structure and substrate specificity, contributing to its specific role in immunological function, inflammation, and lipid metabolism. As the most recently identified member of the HDAC family, HDAC11's precise physiological roles are still being elucidated, but emerging research suggests its involvement in the regulation of immune responses and the differentiation of fat cells, indicating its impact on various diseases, including cancer, metabolic disorders, and autoimmune diseases. The ability of HDAC11 to modulate gene expression and cellular processes underscores the importance of its regulation for maintaining cellular homeostasis and responding to physiological and pathological stimuli. The inhibition of HDAC11 represents a strategic approach to modulating its regulatory effects on gene expression and chromatin structure. Inhibition can occur through various mechanisms, including the use of small molecule inhibitors that bind to the active site of HDAC11, blocking its deacetylase activity. This leads to increased acetylation of histones, resulting in a more open chromatin structure and activation of gene transcription. Such inhibitors can be designed to target HDAC11 specifically or to have broader specificity within the HDAC family.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Mocetinostat

726169-73-9sc-364539
sc-364539B
sc-364539A
5 mg
10 mg
50 mg
$210.00
$242.00
$1434.00
2
(1)

Mocetinostat (CAS 726169-73-9) is a chemical compound that functions as an inhibitor of HDAC11, a specific histone deacetylase enzyme. Its molecular properties enable it to selectively target and block HDAC11 activity, potentially impacting cellular processes and gene expression regulation.

JNJ-26481585

875320-29-9sc-364515
sc-364515A
5 mg
50 mg
$321.00
$1224.00
(1)

JNJ-26481585 (CAS 875320-29-9) is a chemical compound known for its function as an inhibitor of HDAC11, a specific histone deacetylase enzyme. It modulates HDAC11 activity, affecting epigenetic processes within a research lab setting.

Scriptaid

287383-59-9sc-202807
sc-202807A
1 mg
5 mg
$63.00
$179.00
11
(2)

Scriptaid is an HDAC inhibitor that has been reported to inhibit HDAC11 along with other HDAC family members. It was originally identified as an enhancer of the reprogramming of somatic cells into induced pluripotent stem cells.

PI3K/HDAC Inhibitor

1339928-25-4sc-364584
sc-364584A
5 mg
10 mg
$340.00
$462.00
(0)

The chemical "PI3K/HDAC Inhibitor" (CAS 1339928-25-4) is a compound known for its inhibitory action specifically targeting HDAC11, a histone deacetylase enzyme. By selectively inhibiting HDAC11, it modulates cellular acetylation processes, which can have various effects on cellular functions.

Panobinostat

404950-80-7sc-208148
10 mg
$196.00
9
(1)

Panobinostat is a pan-HDAC inhibitor that has been studies for its potential myeloma fighting properties. While it primarily targets HDACs 1, 2, 3, and 6, it may also have some effect on HDAC11.

Belinostat

414864-00-9sc-269851
sc-269851A
10 mg
100 mg
$153.00
$561.00
(1)

Belinostat is a pan-HDAC inhibitor that has been studies for its potential peripheral T-cell lymphoma fighting properties. It primarily targets HDACs 1, 2, 3, and 6 but may also have effects on HDAC11.

Valproic Acid

99-66-1sc-213144
10 g
$85.00
9
(1)

Valproic acid is an approved drug used for epilepsy and bipolar disorder. It is also known to have HDAC inhibitory activity, including some effect on HDAC11.

MS-275

209783-80-2sc-279455
sc-279455A
sc-279455B
1 mg
5 mg
25 mg
$24.00
$88.00
$208.00
24
(2)

Entinostat is a selective inhibitor of HDAC1 and HDAC3. It has been tested in research trials for various cancer therapies.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$130.00
$270.00
37
(2)

Vorinostat is a pan-HDAC inhibitor which targets HDACs 1, 2, 3, and 6, and may also inhibit HDAC11 to some extent.

ITF2357

732302-99-7sc-364513
sc-364513A
5 mg
50 mg
$340.00
$1950.00
(0)

Givinostat is a potent pan-HDAC inhibitor with therapeutic potential in various inflammatory and autoimmune diseases. It targets multiple HDAC family members, including HDAC11.