HCF1 Activators
The collection of chemicals known as HCF1 Activators are diverse in their structures and primary targets, yet they share a common thread in their ability to either directly or indirectly modulate the function of the HCF1 protein. Their actions range from the direct modulation of cellular signaling pathways to more indirect effects on gene expression and chromatin structure. For instance, some of these activators, like EGF and Forskolin, primarily function by modulating signaling pathways that are directly related to HCF1 function. EGF, for instance, binds to its receptor EGFR, triggering a signaling cascade that ultimately leads to the increased expression of HCF1. Similarly, Forskolin, by activating adenylyl cyclase, influences the PKA pathway and potentially initiates a cascade of events leading to HCF-1 activation.
On theother hand, some activators like Retinoic acid and Sodium butyrate exert their influence in a more indirect manner. Retinoic acid, a metabolite of vitamin A, mediates cellular growth and differentiation by binding to its receptors (RARs), which can modulate the expression of genes involved in cell cycle progression where HCF-1 plays a critical role. Sodium butyrate is a histone deacetylase (HDAC) inhibitor that modifies chromatin structure to impact gene expression, potentially leading to the activation of HCF-1. Interestingly, some compounds such as Staurosporine and H-89 dihydrochloride primarily function as inhibitors of certain proteins but can still potentially lead to HCF1 activation. Staurosporine is a potent inhibitor of protein kinases, and by inhibiting these kinases, it can affect various cellular processes, including those involving HCF-1. Similarly, H-89 dihydrochloride, an inhibitor of protein kinase A (PKA), can influence downstream signaling pathways and potentially lead to HCF-1 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is a metabolite of vitamin A (retinol) that mediates cellular growth and differentiation in both embryonic and adult tissues. It can influence HCF-1 indirectly through its role in the regulation of gene expression. Retinoic acid receptors (RARs), upon ligand binding, can modulate the expression of genes involved in cell cycle progression, where HCF-1 plays a crucial role. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpene that activates adenylyl cyclase, an enzyme involved in regulating many cellular functions. By increasing cyclic AMP levels, forskolin can influence the PKA pathway, which can potentially initiate a cascade of events that lead to HCF-1 activation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including Protein Kinase C (PKC). The inhibition of PKC can affect a variety of downstream cellular processes, including those in which HCF-1 is involved, such as cell cycle regulation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, the overall phosphorylation state of a cell is increased, which can affect a variety of cellular processes and pathways, potentially leading to the activation of HCF-1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of Protein Kinase C (PKC) and downstream signaling pathways. This can lead to changes in gene expression, including the activation of HCF-1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can modulate a variety of signaling pathways. Its action on these pathways could potentially lead to the activation of HCF-1. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that acts as a histone deacetylase (HDAC) inhibitor, influencing gene expression by modifying chromatin structure. This can lead to the activation of downstream proteins such as HCF-1. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that influences gene transcription. It can affect a variety of cellular processes, potentially leading to the activation of HCF-1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a central regulator of cell growth and proliferation. By inhibiting mTOR, rapamycin can influence the cell cycle and other cellular processes, potentially leading to the activation of HCF-1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride is a compound that inhibits Glycogen synthase kinase 3 (GSK-3). The inhibition of GSK-3 can lead to the alteration of a variety of cellular processes, including those in which HCF-1 is involved, thus potentially leading to its activation. | ||||||