HCC-1 Inhibitors
HCC-1 inhibitors are a class of chemical compounds that function by selectively targeting and modulating the activity of the HCC-1 protein, which is a member of the chemokine family. Chemokines are small signaling proteins that mediate immune responses, and HCC-1 (also known as CCL14) is primarily involved in regulating the movement and activity of immune cells. Inhibitors of HCC-1 are designed to interfere with the binding of this chemokine to its corresponding receptors, thus altering the downstream signaling pathways involved in immune cell trafficking, adhesion, and activation. These inhibitors typically possess structures that allow them to compete with endogenous ligands or interact with allosteric sites on the chemokine or its receptor, thereby modulating the biological functions associated with HCC-1.
Structurally, HCC-1 inhibitors often feature characteristics that enable high specificity and affinity for the chemokine or its receptor, which is critical to effectively disrupt its function. These compounds may range from small molecules to larger peptides, each designed to fit key binding domains. The design of such inhibitors is based on an understanding of the protein's three-dimensional structure, which allows for the development of molecules that can precisely interact with HCC-1. By binding to the chemokine or blocking its receptor, these inhibitors interfere with the molecular interactions and signaling cascades triggered by HCC-1, which can influence various physiological processes. The specificity and binding affinity of these inhibitors are typically assessed through biochemical assays that examine their effects on HCC-1 signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may suppress HCC-1 expression by inhibiting the transcriptional activity of NF-κB, a factor known to promote the transcription of various inflammatory genes including HCC-1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could downregulate HCC-1 by hindering the signal transduction of pro-inflammatory pathways, potentially leading to a decrease in HCC-1 gene transcription. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin may trigger the activation of AMP-activated protein kinase (AMPK), leading to an anti-inflammatory state that includes the decreased expression of HCC-1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid has the potential to reduce HCC-1 through the alteration of gene expression profiles during the process of cellular differentiation and maturation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin could decrease HCC-1 levels by inhibiting mammalian target of rapamycin (mTOR), a central regulator of cell metabolism, growth, and proliferation, which could in turn lead to reduced pro-inflammatory signaling. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin may suppress HCC-1 expression by inhibiting cyclooxygenase-1 and -2 (COX-1 and COX-2), key enzymes in the prostaglandin synthesis pathway, thereby reducing inflammatory mediators that stimulate HCC-1 expression. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib could inhibit the expression of HCC-1 by blocking kinase activity, thereby leading to a decrease in cellular proliferation signals that may be responsible for the upregulation of HCC-1 in certain cellular contexts. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Sulindac may reduce HCC-1 expression by inhibiting the activation of the NF-κB pathway, a mechanism that could lead to a decrease in the expression of several pro-inflammatory genes, including HCC-1. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine could decrease HCC-1 expression by diminishing the immune system's activation state, which may include the downregulation of cytokine signaling that prompts HCC-1 expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059, by inhibiting MEK1/2, has the potential to decrease HCC-1 expression as it may blunt the MAPK/ERK signaling cascade, a pathway often associated with the transcriptional control of numerous inflammatory genes. | ||||||