vhCAP-G inhibitors belong to a distinctive chemical class primarily characterized by their ability to target and modulate the activity of the human condensin-associated protein G (hCAP-G). Condensins are vital components involved in the organization and regulation of chromatin structure during various cellular processes, particularly in mitosis and interphase. hCAP-G is a crucial subunit of the condensin complex, playing a pivotal role in ensuring proper chromosome segregation and maintenance of genomic integrity. The inhibitors specifically interact with hCAP-G, exerting their effects by disrupting the condensin complex's normal function. By impeding the activity of hCAP-G, these inhibitors influence the condensation and organization of chromatin, potentially leading to altered cell cycle progression and impacting fundamental cellular functions.
hCAP-G inhibitors is characterized by specific functional groups and binding motifs that facilitate their selective interaction with hCAP-G. This targeted binding mechanism distinguishes them from other compounds, allowing for a precise modulation of condensin-associated activities. Research into hCAP-G inhibitors is driven by the aim to comprehend the intricate regulatory mechanisms governing chromatin dynamics, with potential implications for understanding cellular processes such as mitosis and gene expression. These inhibitors serve as valuable tools in experimental settings, aiding researchers in dissecting the molecular intricacies of condensin function and unraveling the broader implications of chromatin organization in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules and prevents their disassembly, thus inhibiting the mitotic spindle. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Binds to tubulin, inhibiting its polymerization and disrupting mitotic spindle assembly. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Destabilizes microtubules, leading to cell cycle arrest at the M-phase. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Inhibits tubulin polymerization and thus mitotic spindle assembly. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Disrupts mitotic spindle by interacting with microtubules, causing metaphase arrest. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Inhibits microtubule growth, leading to G2/M phase arrest. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Inhibits Eg5 kinesin motor protein, affecting spindle pole separation. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
Plk1 inhibitor that leads to mitotic arrest, affecting spindle formation and stability. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
Inhibits Eg5 kinesin motor protein and disrupts mitotic spindle dynamics. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Inhibits cyclin-dependent kinases, which may result in G2/M phase arrest. | ||||||