hCAP-D2 Inhibitors
The class of compounds referred to as hCAP-D2 inhibitors encompasses a diverse group of chemical agents that have demonstrated the ability to impede the function of hCAP-D2, a critical protein involved in the regulation of chromosome condensation and segregation during cell division. hCAP-D2, also known as condensin II complex subunit D2, plays an essential role in ensuring the orderly organization and segregation of genetic material, a process vital for maintaining genomic stability. The inhibition of hCAP-D2 represents a significant area of interest in molecular biology and cellular research, as it sheds light on the mechanisms governing chromosomal dynamics and can provide insights into various cellular processes.
These inhibitors typically target hCAP-D2 by interfering with key molecular pathways associated with chromosomal regulation. Common mechanisms of action include the disruption of enzymes such as topoisomerases I and II, which are involved in DNA replication and repair. By doing so, these compounds induce DNA damage, leading to impaired chromosome condensation and segregation. Other inhibitors, such as those binding to DNA directly, can alter the structural properties of DNA, further affecting hCAP-D2's ability to function correctly. The diverse range of chemical structures and mechanisms of action within this class of inhibitors underscores the importance of understanding the precise molecular interactions that govern hCAP-D2's role in chromosome dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits hCAP-D2 by interfering with topoisomerase II, an enzyme involved in DNA replication and repair. It induces DNA strand breaks, preventing proper chromosome condensation and segregation. | ||||||
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $96.00 $355.00 | ||
Novobiocin inhibits hCAP-D2 by targeting DNA gyrase, which helps maintain chromosome structure. Inhibition of DNA gyrase leads to disruptions in chromosome organization and segregation. | ||||||
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $330.00 $898.00 | 7 | |
ICRF-193 inhibits hCAP-D2 by interfering with topoisomerase II and preventing it from resolving DNA tangles. This disruption leads to aberrant chromosome structure. | ||||||
Quinacrine, Dihydrochloride | 69-05-6 | sc-204222 sc-204222B sc-204222A sc-204222C sc-204222D | 100 mg 1 g 5 g 200 g 300 g | $45.00 $56.00 $85.00 $3193.00 $4726.00 | 4 | |
Quinacrine inhibits hCAP-D2 by binding to DNA and preventing its proper condensation, ultimately affecting chromosome segregation. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin induces DNA damage and inhibits hCAP-D2 by causing DNA breaks, impairing proper chromosome condensation and segregation. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits hCAP-D2 by targeting topoisomerase I, resulting in DNA strand breaks and affecting chromosome structure and segregation. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin inhibits hCAP-D2 by intercalating into DNA and inhibiting topoisomerase II, causing DNA damage and affecting chromosome segregation. | ||||||
Mitoxantrone Dihydrochloride | 70476-82-3 | sc-203136 sc-203136A sc-203136B sc-203136C | 10 mg 50 mg 100 mg 1 g | $42.00 $68.00 $126.00 $785.00 | 6 | |
Mitoxantrone inhibits hCAP-D2 by targeting topoisomerase II and inducing DNA damage, leading to defects in chromosome structure and segregation. | ||||||
(+)-Irinotecan | 97682-44-5 | sc-269253 | 10 mg | $61.00 | 1 | |
Irinotecan inhibits hCAP-D2 by targeting topoisomerase I, resulting in DNA strand breaks and disrupting chromosome condensation and segregation. | ||||||
Teniposide | 29767-20-2 | sc-204910 sc-204910A | 25 mg 100 mg | $72.00 $230.00 | 6 | |
Teniposide inhibits hCAP-D2 via topoisomerase II inhibition, causing DNA damage and affecting chromosome structure and segregation during cell division. | ||||||