GS2-like Activators
GS2-like activators are a specialized group of chemical compounds that influence various cellular signaling pathways, leading to the enhanced functional activity of GS2-like. Forskolin and IBMX work synergistically to increase intracellular cAMP levels, which in turn activate protein kinase A (PKA). PKA is known to phosphorylate specific substrates that are involved in lipid metabolism, thereby directly enhancing the activity of GS2-like. Nicotinamide riboside, as a precursor of NAD+, increases the availability of NAD+ which is essential for the deacetylase functions of sirtuins. Enhanced sirtuin activity leads to deacetylation and activation of GS2-like, promoting its role in lipid metabolism. Palmitoylethanolamide and Oleoylethanolamide engage and activate peroxisome proliferator-activated receptors (PPARs), which are nuclear receptors that can initiate transcriptional responses leading to the enhanced activity of GS2-like in lipolysis.
In parallel, compounds like L-α-Lysophosphatidylinositol and Sphingosine-1-phosphate activate G-protein coupled receptors and receptor tyrosine kinases, respectively, leading to the activation of downstream MAPK signaling. This signaling cascade effectively enhances GS2-like activity by modulating lipid signaling pathways. Capsaicin, through activation of transient receptor potential vanilloid 1 (TRPV1), induces an increase in intracellular calcium concentration, which can activate calcium-dependent kinases that in turn enhance the lipid metabolism processes governed by GS2-like. Lastly, Resveratrol and Curcumin both modulate the activity of sirtuins and NF-κB signaling, respectively, contributing to the activation of GS2-like by fostering an environment that promotes lipid metabolism over inflammatory responses. PPARγ agonists like Rosiglitazone and Pioglitazone further enhance GS2-like activity by stimulating the transcription of genes that encode proteins crucial for lipid metabolism, emphasizing the role of GS2-like in adipocyte function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP enhances the activity of protein kinase A (PKA), which in turn can phosphorylate GS2-like, enhancing its functional activity in the lipid metabolism process. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX acts as a non-selective inhibitor of phosphodiesterases, preventing the degradation of cAMP. Higher cAMP levels result in the activation of PKA, which may subsequently phosphorylate GS2-like and thus promote its activity in lipid hydrolysis. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside is a precursor of NAD+, which is involved in redox reactions. Elevated NAD+ can enhance sirtuin activity, which may deacetylate and thus activate GS2-like, affecting its role in lipid metabolism. | ||||||
Palmitoylethanolamide | 544-31-0 | sc-202754 sc-202754A sc-202754B sc-202754C sc-202754D | 10 mg 50 mg 500 mg 1 g 10 g | $78.00 $238.00 $2050.00 $3274.00 $16330.00 | ||
Palmitoylethanolamide, a fatty acid ethanolamide, can enhance endocannabinoid signaling. This activation might influence GS2-like by altering lipid signaling pathways that GS2-like is involved in, thereby promoting its activity in lipolysis. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $88.00 $190.00 | 1 | |
Oleoylethanolamide, another fatty acid ethanolamide, engages peroxisome proliferator-activated receptors (PPARs). PPAR activation can lead to co-activator recruitment for transcription factors that enhance GS2-like activity in regulating lipid metabolism. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate binds to its receptors on the cell surface, leading to downstream MAPK activation. This activation could enhance the activity of GS2-like by influencing lipid signaling pathways GS2-like is involved in. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates transient receptor potential vanilloid 1 (TRPV1) which can lead to increased intracellular calcium levels. This elevation in calcium may activate calcium-dependent kinases that enhance GS2-like's role in lipid metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, an NAD-dependent deacetylase. Activation of SIRT1 can lead to the deacetylation and activation of GS2-like, thereby influencing lipid metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, which might reduce the inflammatory response, thus potentially reducing the inhibition of lipid metabolism pathways where GS2-like plays a role, enhancing its activity. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a PPARγ agonist, and its activation can lead to the transcription of genes involved in lipid metabolism, potentially enhancing the activity of GS2-like in adipocytes. | ||||||