Date published: 2025-9-10

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GRIN3 Activators

Activators of GRIN3, also known as GPRIN3 (G protein-regulated inducer of neurite outgrowth 3), represent a captivating class of compounds with intricate involvement in various cellular processes and signaling pathways. Notably, GRIN3 has been identified as a selective controller of dopamine receptor D2 (D2R) function in the striatum, where it plays a pivotal role in striatal-associated behaviors and cellular functions. It contributes to the regulation of dopamine-dependent behaviors and is essential for the activation of dopamine receptors, particularly in the context of the DAR-beta-arrestin signaling cascade 1. This highlights the multifaceted nature of GRIN3, extending beyond its role as an NMDA receptor subunit modulator. Moreover, GRIN3's presence and significance span across multiple tissues, as observed in studies involving GRIN3 knockout mice. Expression levels of endogenous GRIN3 have been investigated in various tissues, including the striatum, whole brain, heart, liver, thymus, lung, and kidney 2. This suggests that GRIN3 may have diverse roles beyond its neural functions. Additionally, GRIN3 belongs to the G protein-regulated inducer of neurite growth (GRIN) family, alongside GRIN1 and GRIN2 isoforms. These proteins interact with the Gαi/o subfamily of G proteins, thereby mediating signal processing via G protein-coupled receptors (GPCRs). This implicates GRIN3 in intricate signaling pathways, possibly influencing a wide range of cellular responses 3. Furthermore, it is speculated that GRIN3 may play a role in neurite outgrowth, hinting at its potential involvement in neuron development or regeneration 4. These multifaceted characteristics underscore the importance of GRIN3 in cellular and neuronal biology, making it a focal point for ongoing research.

SEE ALSO...

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Bromocriptine

25614-03-3sc-337602A
sc-337602B
sc-337602
10 mg
100 mg
1 g
$56.00
$260.00
$556.00
4
(1)

Bromocriptine is a dopamine receptor agonist. Since GRIN3 is involved in dopamine receptor regulation, bromocriptine may modulate GRIN3 expression through dopamine receptor signaling.

Cabergoline

81409-90-7sc-203864
sc-203864A
10 mg
50 mg
$300.00
$1055.00
(0)

Cabergoline is a dopamine receptor agonist. With GRIN3's role in dopamine receptor regulation, cabergoline might influence GRIN3 expression via dopamine receptor pathways.

Ropinirole Hydrochloride

91374-20-8sc-205843
sc-205843A
25 mg
100 mg
$82.00
$311.00
1
(0)

Ropinirole is a dopamine agonist. Given GRIN3's involvement in dopamine receptor regulation, ropinirole may modulate dopamine receptor signaling and thereby GRIN3 expression.

(−)-Quinpirole hydrochloride

85798-08-9sc-253339
10 mg
$138.00
1
(1)

Quinpirole is a dopamine agonist. Considering GRIN3's role in dopamine receptor regulation, quinpirole might affect GRIN3 expression through dopamine receptor activation.

SKF 38393 hydrochloride

62717-42-4sc-203264
25 mg
$49.00
(1)

SKF-38393 is a dopamine D1 receptor agonist. GRIN3 is involved in dopamine receptor regulation, thus SKF-38393 may modulate GRIN3 expression via dopamine D1 receptor signaling.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin is an adenylyl cyclase activator. GRIN3 is associated with G protein-coupled signaling, thus forskolin could modulate GPCR signaling and potentially GRIN3 expression.

Picrotoxin

124-87-8sc-202765
sc-202765A
sc-202765B
1 g
5 g
25 g
$66.00
$280.00
$1300.00
11
(3)

Picrotoxin is a GABA_A receptor antagonist. Considering GRIN3's association with G protein-coupled signaling, picrotoxin might affect GPCR signaling and thereby influence GRIN3 expression.

Pertussis Toxin (islet-activating protein)

70323-44-3sc-200837
50 µg
$442.00
3
(1)

Pertussis Toxin is a G protein signaling modulator. With GRIN3's association with G protein-coupled signaling, pertussis toxin could influence GRIN3 expression via G protein-coupled signaling pathways.

Gallein

2103-64-2sc-202631
50 mg
$83.00
20
(1)

Gallein is a Gβγ signaling inhibitor. GRIN3 is associated with G protein-coupled signaling, thus gallein may modulate GPCR signaling and potentially affect GRIN3 expression.

Isoproterenol Hydrochloride

51-30-9sc-202188
sc-202188A
100 mg
500 mg
$27.00
$37.00
5
(0)

Isoproterenol is a β-adrenergic receptor agonist. Given the G protein-coupled signaling association of GRIN3, isoproterenol might modulate GPCR signaling thereby potentially affecting GRIN3 expression.