Pertussis Toxin (islet-activating protein) CAS: 70323-44-3
A toxin that blocks reduction of adenylate cyclase activity.

Pertussis Toxin (islet-activating protein) (CAS 70323-44-3)

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Synonym: PTX;Holotoxin
Application A toxin that blocks reduction of adenylate cyclase activity
CAS 등록번호: 70323-44-3
순도: >99%
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Pertussis Toxin (islet-activating protein), a toxin originally isolated from Bordetella pertussis, has been shown to catalyze ADP-ribosylation of a protein in membrane preparation from rat C6 glioma cells. In addition, exposure of Chinese hamster ovary cells in culture to this compound has resulted in a clustered growth pattern response. Other experiments have shown Pertussis Toxin to block the ability of inhibitory hormones to reduce adenylate cyclase activity and enhance the ability of stimulatory hormones to activate the enzyme. Mechanistic studies have shown this toxin to consist of subunit A (active) promoter, which disrupts transmembrane signaling by ADP-ribosylating eukaryotic G-proteins, and B (binding) oligomer which helps the toxin bind to cells in vivo.


References

1. Tamura, M., et al. 1982. Biochemistry. 21: 5516-5522. PMID: 6293544
2. Hewlett, E.L., et al. 1983. Infect. Immun. 40: 1198-1203. PMID: 6682833
3. Bokoch, G.M., et al. 1983. J. Biol. Chem. 258: 2072-2075. PMID: 6296122
4. Kaslow, H.R., et al. 1987. Biochemistry. 26: 123-127. PMID: 3030399
5. Kaslow, H.R. and Burns, D.L. 1992. FASEB J. 6: 2684-2690. PMID: 1612292

Physical State :
Solid
에서 유래된 :
Bordetella pertussis
용해도 :
Soluble in water (Miscible).
저장 :
Store at 4° C
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
XW5883750
MDL Number :
MFCD00131841

SDS(MSDS)다운로드

분석증명서

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Pertussis Toxin (islet-activating protein)  논문정보

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Citations 1 to 1 of {3} total

PMID: # 3158374  Fujita, N. et al. 1985. Brain Res. 333: 231-236.

Citations 1 to 1 of {3} total
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