granzyme B Substrates

Santa Cruz Biotechnology now offers a broad range of granzyme B substrates for use in various applications. Granzyme B substrates are pivotal in biochemical and cellular studies, particularly in the field of immunology and cell biology. Granzyme B is a serine protease enzyme predominantly expressed in cytotoxic T lymphocytes and natural killer (NK) cells. It plays a crucial role in inducing apoptosis in target cells, a process essential for immune defense and maintaining cellular homeostasis. In research settings, granzyme B substrates are extensively utilized to study the mechanisms of apoptosis and to evaluate the activity and specificity of granzyme B. These substrates, often designed as peptide sequences, are engineered to be cleaved by granzyme B, allowing researchers to measure enzymatic activity through various detection methods such as fluorescence or colorimetry. This capability is instrumental in deciphering the pathways involved in immune responses, cellular cytotoxicity, and the regulation of apoptosis, which are fundamental to understanding diseases, immune disorders, and the basic mechanisms of cell death. By providing a versatile toolset, granzyme B substrates facilitate the exploration of intracellular processes and the characterization of immune cell functions, thus contributing significantly to the advancement of scientific knowledge. View detailed information on our available granzyme B substrates by clicking on the product name.