Molecular structure of Ac-IETD-AFC, CAS Number: 211990-57-7
Ac-IETD-AFC (CAS 211990-57-7)
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Alternate Names:
Caspase-8 Substrate IETD-AFC; N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin
Application:
Ac-IETD-AFC is a substrate for caspase-8/caspase-3 processing enzyme and granzyme B
CAS Number:
211990-57-7
Molecular Weight:
729.65
Molecular Formula:
C31H38F3N5O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ac-IETD-AFC is a potent inhibitor of protein synthesis. It operates by binding to the peptidyl transferase center of the ribosome, effectively impeding the peptidyl transferase reaction necessary for protein synthesis. Additionally, Ac-IETD-AFC binds to the A-site of the ribosome, responsible for the attachment of aminoacyl-tRNA molecules. This binding obstructs the interaction of aminoacyl-tRNA molecules, preventing peptide bond formation and subsequent elongation of the polypeptide chain. Consequently, the inhibition of protein synthesis by Ac-IETD-AFC hampers cell growth, differentiation, and apoptosis. Ac-IETD-AFC has demonstrated the ability to inhibit the translation of specific mRNA molecules, leading to the suppression of distinct cellular processes.
Ac-IETD-AFC (CAS 211990-57-7) References
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Substrate of:
caspase-10, caspase-3, caspase-8, Enzyme, Fluorogenic, and granzyme B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ac-IETD-AFC, 5 mg | sc-311276 | 5 mg | $275.00 | |||
Ac-IETD-AFC, 10 mg | sc-311276A | 10 mg | $444.00 |