Golgin 45 Inhibitors
Golgin 45 inhibitors are a class of chemical compounds that specifically target the Golgin-45 protein, a crucial component of the Golgi apparatus in eukaryotic cells. Golgin-45 is part of the golgin family, which consists of coiled-coil proteins responsible for maintaining the structure and function of the Golgi apparatus. By binding to Golgin-45, these inhibitors interfere with its role in vesicle tethering and membrane fusion processes essential for protein and lipid trafficking within the cell. The inhibition of Golgin-45 can lead to disruptions in Golgi structure, affecting the processing, modification, and sorting of macromolecules. This interference provides a valuable tool for studying the dynamics of intracellular transport and the organizational principles of the Golgi apparatus.
The chemical structures of Golgin-45 inhibitors are diverse but generally contain functional groups that enable high-affinity interactions with the Golgin-45 protein. These interactions often involve binding to specific domains within Golgin-45, such as its coiled-coil regions, which are critical for its dimerization and interaction with other Golgi proteins. Researchers utilize these inhibitors to dissect the molecular mechanisms underlying Golgi function, including vesicle formation, cargo selection, and inter-organelle communication. By modulating Golgin-45 activity, scientists can observe the resultant effects on cellular processes like secretion, endocytosis, and membrane recycling. This contributes to a deeper understanding of cellular homeostasis and the intricate network of protein interactions that sustain it.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
ADP-ribosylation factor (ARF) inhibitor affecting vesicle trafficking. Brefeldin A indirectly influences golgin 45 by disrupting ARF-dependent vesicular transport, leading to alterations in the Golgi apparatus organization. This disruption can impact golgin 45-mediated processes, providing a potential avenue for modulating its cellular functions. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
GTPase inhibitor targeting Golgi-specific GTPases. Golgicide A directly inhibits Golgi-associated GTPases, potentially including those interacting with golgin 45. This direct inhibition can disrupt golgin 45-associated processes, offering a specific approach for modulating its cellular functions. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $84.00 $297.00 | 4 | |
Golgi-derived vesicle trafficking inhibitor. Exo1 indirectly influences golgin 45 by disrupting Golgi vesicle transport, leading to alterations in Golgi organization. This disruption can impact golgin 45-mediated processes, providing a potential avenue for modulating its cellular functions. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Ionophore disrupting ion gradients and vesicle trafficking. Monensin indirectly influences golgin 45 by disrupting Golgi vesicle transport and ion gradients, leading to alterations in Golgi organization. This disruption can impact golgin 45-mediated processes, providing a potential avenue for modulating its cellular functions. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
Small molecule inhibitor of GBF1 affecting Golgi organization. SecinH3 indirectly influences golgin 45 by disrupting GBF1-mediated processes, leading to alterations in Golgi structure. This disruption can impact golgin 45-associated functions, providing a potential avenue for modulating its cellular activities. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $104.00 $416.00 $655.00 $1301.00 | 10 | |
Glutamine amidotransferase inhibitor affecting Golgi organization. Acivicin indirectly influences golgin 45 by disrupting processes dependent on glutamine amidotransferase activity, leading to alterations in Golgi structure. This disruption can impact golgin 45-associated functions, providing a potential avenue for modulating its cellular activities. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Microtubule polymerization inhibitor impacting Golgi structure. Nocodazole indirectly influences golgin 45 by disrupting microtubule dynamics, leading to alterations in Golgi organization. This disruption can impact golgin 45-associated functions, providing a potential avenue for modulating its cellular activities. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Rho-associated protein kinase (ROCK) inhibitor affecting Golgi structure. Y-27632 indirectly influences golgin 45 by modulating ROCK activity and downstream pathways, leading to alterations in Golgi organization. This disruption can impact golgin 45-associated functions, providing a potential avenue for modulating its cellular activities. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Calcium chelator impacting Golgi organization. BAPTA-AM indirectly influences golgin 45 by disrupting calcium-dependent processes, leading to alterations in Golgi structure. This disruption can impact golgin 45-associated functions, providing a potential avenue for modulating its cellular activities. | ||||||