golgin 45 Activators
Golgin 45 activators are chemical compounds that indirectly promote the functional activity of golgin 45 by modulating specific cellular pathways and processes. Phosphatidic acid, by influencing membrane dynamics, enhances the structural integrity of the Golgi apparatus, which is central to golgin 45's role in membrane tethering. Similarly, GTPγS activates GTP-binding proteins, indirectly supporting the vesicle transport processes that are critical for golgin 45 function in the Golgi. The action of N-Ethylmaleimide, by inhibiting NSF and therefore increasing the vesicle pool, could indirectly lead to an upsurge in golgin 45-mediated vesicle tethering. Calcium fluxes induced by A23187 may influence golgin 45's activity by modulating calcium-dependent signaling pathways, while Forskolin's upregulation of cAMP levels may enhance golgin 45 function via PKA phosphorylation pathways.
Furthermore, Monensin's modulation of Golgi pH and subsequent effect on vesicle trafficking could result in an enhanced requirement for golgin 45 activity in vesicle tethering. Nitric oxide donors, through protein S-nitrosylation, can influence docking and fusion events, potentially augmenting golgin 45's role. Taxol stabilizes microtubules which are essential for vesicle transport, indirectly facilitating golgin 45 function in vesicle tethering to the Golgi. Guanabenz affects the unfolded protein response, which may indirectly necessitate an increased role for golgin 45 in Golgi maintenance. Nicotinamide mononucleotide, by enhancing NAD+ biosynthesis, could optimize cellular metabolism for protein trafficking and sorting, thereby supporting golgin 45's role in these processes. Lastly, Dibucaine's modulation of calcium channels may lead to an improved functional activity of golgin 45 in calcium-dependent vesicle fusion at the Golgi apparatus.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phosphatidic Acid, Dipalmitoyl | 169051-60-9 | sc-201057 sc-201057B sc-201057A | 100 mg 250 mg 500 mg | $104.00 $239.00 $409.00 | ||
Phosphatidic acid plays a role in membrane curvature and trafficking, which can enhance the activity of golgin 45 by promoting Golgi apparatus structure and integrity. This would indirectly lead to an increased functional activity of golgin 45 due to its involvement in Golgi-membrane tethering. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $456.00 | ||
GTPγS, a non-hydrolysable analogue of GTP, can activate small GTPases involved in vesicle transport, potentially enhancing golgin 45 function by increasing the efficiency of vesicular trafficking to the Golgi apparatus where golgin 45 operates. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
N-Ethylmaleimide can inhibit NSF (N-ethylmaleimide-sensitive factor), which is necessary for vesicle fusion. By inhibiting NSF, N-Ethylmaleimide may increase the pool of vesicles available for tethering by golgin 45, indirectly enhancing its functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium concentrations, which can influence the calcium-dependent signaling pathways that golgin 45 may be involved in, thus enhancing its role in Golgi apparatus function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates cAMP levels, which may enhance golgin 45 activity by promoting vesicle transport to the Golgi via PKA phosphorylation of associated proteins, indirectly aiding golgin 45's tethering function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that alters Golgi pH and can affect vesicle trafficking. This alteration might enhance the activity of golgin 45 by modulating the Golgi apparatus environment to favor golgin 45-mediated vesicle tethering. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
Nitric oxide donors release nitric oxide which can S-nitrosylate proteins and thus modify trafficking pathways. This modification could enhance golgin 45 function by impacting the vesicle docking and fusion events in which golgin 45 participates. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules, which are essential for vesicle transport to the Golgi. Stabilized microtubules can indirectly enhance the role of golgin 45 in vesicle tethering and fusion by ensuring efficient delivery to the Golgi apparatus. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $100.00 $459.00 $816.00 $4080.00 $7140.00 | 2 | |
Guanabenz interferes with the unfolded protein response, potentially impacting Golgi function. This interference could lead to an increased need for the function of golgin 45, indirectly enhancing its activity in Golgi apparatus maintenance. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN is a precursor in the NAD+ biosynthesis pathway, which is important for cellular metabolism, including the trafficking and sorting of proteins. Elevated NAD+ levels can indirectly enhance golgin 45 activity by optimizing cellular energy status for trafficking processes. | ||||||